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Pharmacokinetics of trimethoprim/sulfametrole in critically ill patients on continuous renal replacement therapy.
J Antimicrob Chemother
May 2020
Clinical Pharmacokinetics Unit, Division of Intensive Care and Emergency Medicine, Department of Internal Medicine I, Medical University of Innsbruck, Innsbruck, Austria.
Objectives: We investigated the effect of continuous renal replacement therapy (CRRT) on the pharmacokinetics of trimethoprim and sulfametrole.
Patients And Methods: We enrolled critically ill adults undergoing CRRT and critically ill adults with normal or slightly impaired renal function (plasma creatinine concentration <1.5 mg/dL, control group).
Development and Validation of an HPLC-UV Assay to Quantify Plasma Levels of Sulfametrol: A Preferential Antibiotic in Children.
Ther Drug Monit
October 2015
Hospital Pharmacy Erasmus MC, Rotterdam, the Netherlands.
Background: Sulfonamides in combination with trimethoprim are frequently used antibiotics. They work synergistic. In infections with Pneumocystis jiroveci or Stenotrophomonas maltophilia, higher dosages are indicated than in other infections.
View Article and Find Full Text PDFComparative in vitro activity of sulfametrole/trimethoprim and sulfamethoxazole/trimethoprim and other agents against multiresistant Gram-negative bacteria.
J Antimicrob Chemother
April 2014
Antimicrobial Resistance and Healthcare Associated Infections Reference Unit, Public Health England, London NW9 5EQ, UK.
Objectives: Sulfamethoxazole/trimethoprim is standard therapy for infections caused by opportunist non-fermenters except Pseudomonas aeruginosa and Acinetobacter. Sulfametrol(e)/trimethoprim is an alternative to sulfamethoxazole/trimethoprim available in some EU countries, with possible pharmacological advantages. We compared their activities against (i) non-fermenters, (ii) multiresistant Enterobacteriaceae and (iii) reference strains with sul1 and sul2.
View Article and Find Full Text PDFSynthesis, spectroscopic, thermal and antimicrobial studies of some novel metal complexes of Schiff base derived from [N1-(4-methoxy-1,2,5-thiadiazol-3-yl)sulfanilamide] and 2-thiophene carboxaldehyde.
Spectrochim Acta A Mol Biomol Spectrosc
April 2007
Chemistry Department, Faculty of Science, Al-Azhar University (Girls), Nasr City, Cairo, Egypt.
Keeping in view the chemotherapeutic of the sulfa-drugs, Schiff base namely 2-thiophene carboxaldehyde-sulfametrole (HL) and its tri-positive and di-positive metal complexes have been synthesized and characterized by elemental analyses, IR, 1H NMR, solid reflectance, magnetic moment, molar conductance, mass spectra, UV-vis and thermal analysis (TGA and DrTG). The low molar conductance values suggest the non-electrolytic nature of these complexes. IR spectra show that HL is coordinated to the metal ions in a tetradentate manner through hetero five-membered ring-S and azomethine-N, enolic sulfonamide-OH and thiadiazole-N, respectively.
View Article and Find Full Text PDFMetal complexes of Schiff base derived from sulphametrole and o-vanilin. Synthesis, spectral, thermal characterization and biological activity.
Spectrochim Acta A Mol Biomol Spectrosc
April 2007
Chemistry Department, Faculty of Science, Cairo University, Giza, Egypt.
Metal complexes of Schiff base derived from condensation of o-vanilin (3-methoxysalicylaldehyde) and sulfametrole [N(1)-(4-methoxy-1,2,5-thiadiazole-3-yl)sulfanilamide] (H2L) are reported and characterized based on elemental analyses, IR, 1H NMR, solid reflectance, magnetic moment, molar conductance, mass spectra, UV-vis and thermal analysis (TGA). From the elemental analyses data, the complexes were proposed to have the general formulae [M2X3(HL)(H2O)5].yH2O (where M=Mn(II), Co(II), Ni(II), Cu(II), Zn(II) and Cd(II), X=Cl, y=0-3); [Fe2Cl5(HL)(H2O)3].
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