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Therapeutic Potential of Combined 5% Lifitegrast and Tocopherol Eye Drops in Managing Inflammation and Oxidative Stress in Murine Dry Eye.
Pharmaceuticals (Basel)
January 2025
Department of Ophthalmology, Chonnam National University Medical School and Hospital, Gwangju 61469, Republic of Korea.
: This study aimed to evaluate the therapeutic effects of combined 5% lifitegrast (LF) and tocopherol (TCP) eye drops in a murine experimental dry eye (EDE) model. Female C57BL/6 were divided into seven groups: untreated controls, EDE control, EDE + 0.05% cyclosporin A (CsA), EDE + tocopherol (TCP), EDE + 5% LF, EDE + 5% LF + TCP (once daily), and EDE + 5% LF + TCP (twice daily).
View Article and Find Full Text PDFWhen a Small Amount of Comonomer Is Enough: Tailoring the Critical Solution Temperature of LCST-Type Thermoresponsive Random Copolymers by PEG Methyl Ether Methacrylate with 1100 g/mol Molecular Weight.
Materials (Basel)
January 2025
Polymer Chemistry and Physics Research Group, Institute of Materials and Environmental Chemistry, HUN-REN Research Centre for Natural Sciences, Magyar Tudósok Körútja 2, H-1117 Budapest, Hungary.
Tuning the critical solution temperature (CST) of thermoresponsive polymers is essential to exploit their immense potential in various applications. In the present study, the effect of PEG-methyl ether methacrylate with a higher molecular weight of 1100 g/mol (mPEGMA) as a comonomer was investigated for its suitability for the CST adjustment of LCST-type polymers. Accordingly, a library of mPEGMA-based copolymers was established with varying compositions () using four main comonomers, namely di(ethylene glycol) ethyl ether acrylate, -isopropyl acrylamide and methacrylamide, and mPEGMA, with different CST values (cloud points, , and clearing points, , by turbidimetry).
View Article and Find Full Text PDF3D printed clear resin stir bar sorptive extraction coupled with high performance liquid chromatography for trace chlorophenols analysis in environmental water samples.
J Chromatogr A
January 2025
Department of Chemistry, Wuhan University, Wuhan 430072, China. Electronic address:
3D printing is an additive manufacturing technology based on digital model files. 3D printing has become a popular manufacturing tool in various fields. Stereolithography offers a series of advantages compared to its counterparts, such as smooth prints, appropriate resolution in all the axes, acceptable organic solvent compatibility and sufficient tightness to the flowing of solutions/solvents at moderate/high pressure.
View Article and Find Full Text PDFDosimetric and Radiobiological Impact of Patient Setup Errors in Intensity-modulated Radiotherapy for Esophageal Cancer.
Technol Cancer Res Treat
January 2025
Department of Radiation Oncology, Cancer Hospital of Shantou University Medical College, Shantou, Guangdong, PR China.
Purpose: To evaluate the impact of patient setup errors on the dosimetry and radiobiological models of intensity-modulated radiotherapy (IMRT) for esophageal cancer.
Methods And Materials: This retrospective study with 56 patients in thermoplastic mask (TM) and vacuum bag (VB) groups utilized real setup-error (RSE) data from cone-beam CT scans to generate simulated setup-error (SSE) data following a normal distribution. The SSE data were applied to simulate all treatment fractions per patient by shifting the plan isocenter and recalculating the dose.
CuTCP: Custom Text Generation-based Class-aware Prompt Tuning for visual-language models.
Sci Rep
January 2025
Zhengzhou University of Light Industry, Zhengzhou, 450001, China.
Visual-language models (VLMs) excel in cross-modal reasoning by synthesizing visual and linguistic features. Recent VLMs use prompt learning for fine-tuning, allowing adaptation to various downstream tasks. TCP applies class-aware prompt tuning to improve VLMs generalization, yet its reliance on fixed text templates as prior knowledge can limit adaptability to fine-grained category distinctions.
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