The emergence of the Klebsiella pneumoniae carbapenemases in K. pneumoniae and other Gram-negative bacteria, usually on a background of multidrug resistance, has led to difficult therapeutic choices. Among available antibiotics, tigecycline and the polymyxins are the most frequently active against these organisms in vitro. Optimal therapy of infections due to these bacteria may involve maximization of antibiotic dose as well as their use in combination.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2948324 | PMC |
| http://dx.doi.org/10.3410/M1-79 | DOI Listing |
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