Bacillary angiomatosis is a well-recognized infection with cutaneous and systemic manifestations caused by Bartonella henselae or Bartonella quintana and occurs in immunocompromised patients. We report a case of B. quintana bacillary angiomatosis following fludarabine-based chemotherapy for chronic lymphocytic leukaemia that was refractory to standard treatment and was complicated by lymphadenopathy and osteomyelitis.
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A 34-year-old male patient presented with a clinical picture of multilocular subcutaneous skin nodules in addition to marked lymphadenopathy and general physical deterioration. A comprehensive diagnostic workup including serology, skin biopsy and imaging studies led to the initial diagnosis of human immunodeficiency virus (HIV) infection in AIDS stage with rare multilocular subcutaneous bacillary angiomatosis (BA) caused by Bartonella henselae. BA describes a process of neovascularisation of the skin or of internal organs (particularly the liver and spleen) and was first described in HIV-positive patients by Stoler et al.
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Laboratory of Bacterial Zoonoses, International Research Center for Infectious Diseases, Research Institute for Microbial Diseases, Osaka University, Suita, Osaka, Japan.
a Gram-negative facultative intracellular bacterium, is the etiological agent of cat-scratch disease and also causes bacillary angiomatosis in immunocompromised individuals. Although the ability to promote vascular endothelial cell proliferation differs among species, variations among strains within remain unclear. angiogenic factor A (BafA) and adhesin A (BadA) have been identified as autotransporters of that are involved in endothelial cell proliferation.
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- Bartonella quintana infection can cause serious health issues like bacillary angiomatosis and culture-negative endocarditis, mainly affecting individuals who are homeless.
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PLoS One
November 2024
Institute of Veterinary Pathology, Vetsuisse Faculty, University of Zurich, Zurich, Switzerland.
Article Synopsis
- - The study details rare cases of skin tumors in Brazilian rainbow boas, identifying conditions similar to hemangioma and hemangioendothelioma, and examining possible links to boid inclusion body disease (BIBD).
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Donor-derived bartonellosis in solid organ transplant recipients from unhoused donors in Alberta.
Am J Transplant
September 2024
Division of Infectious Diseases, Department of Medicine, University of Alberta, Edmonton, Alberta, Canada.
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