AI Article Synopsis
- The study aimed to assess the postoperative survival and effectiveness of known prognostic scores in patients undergoing surgery for a single brain metastasis.
- In a group of 74 patients, factors like good performance status and the absence of extracranial metastases were linked to better overall survival, while immediate whole-brain radiotherapy (WBRT) did not significantly extend survival.
- The study found that certain prognostic scores (RPA and GPA) were useful for identifying patients with very good or very poor prognosis, but further validation in larger populations is needed to confirm these findings.
Article Abstract
Objective: To evaluate postoperative prognosis and the performance of known prognostic scores in patients treated with surgical resection for single brain metastasis.
Methods: We evaluated prognostic factors and five previously published prognostic scores in a group of 74 patients with single brain metastasis treated with surgery with or without immediate whole-brain radiotherapy (WBRT).
Results: In multivariate analysis, good performance status, absence of extracranial metastases and primary tumor control were significantly associated with improved overall survival. Survival (median 10.8 months) was not significantly prolonged by immediate WBRT. Salvage treatment was necessary in 87% of patients without immediate WBRT. All five scores identified groups of patients with superior prognosis. The recursive partitioning analysis (RPA) classes, the graded prognostic assessment (GPA) score and the score developed by Rades et al. identified a poor prognosis group, but the numbers of poor prognosis patients were very small.
Conclusions: RPA and GPA appear to have the most utility in delineating exceptionally good or poor prognosis patients after resection of single brain metastasis, but this finding remains to be validated in a larger study population. Identification and validation of suitable prognostic scores hopefully will guide decision making regarding local treatment of solitary brain metastasis.
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| http://dx.doi.org/10.1016/j.clineuro.2010.09.009 | DOI Listing |
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