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Hydrogen attenuates ischaemia-reperfusion injury in skeletal muscles post-limb replantation by activating the NRF2/HO-1 signalling pathway to reduce BAX expression.
Heliyon
September 2024
Department of Emergency, Zhongshan Hospital Xiamen University, School of Medicine, Xiamen University, Xiamen, China.
Background: Ischaemia-reperfusion injury (IRI) is a critical complication post-limb replantation. The oxidative stress and cellular apoptosis due to IRI considerably hinder the healing process. This study aimed to investigate the modulatory effects of pre-perfusion with hydrogen-rich heparin sodium on the nuclear factor erythroid 2-related factor 2 (NRF2)/haeme oxygenase-1 (HO-1) pathway and its potential mechanisms in mitigating skeletal muscle IRI post-limb replantation.
View Article and Find Full Text PDFTwo {Cu[PMo]}-Based Coordination Polymers Incorporating In Situ Converted Tetrapyridyl Ligands for Trace Analysis of Nitrofuran Antibiotics.
Inorg Chem
May 2024
Liaoning Professional Technology Innovation Center of Liaoning Province for Conversion Materials of Solar Cell, College of Chemistry and Materials Engineering, Bohai University, Jinzhou 121013, China.
Nitrofurans are important synthetic broad-spectrum antibacterial drugs with the basic structure of 5-nitrofuran. Due to their toxicity, it is essential to develop a sensitive sensor with strong anti-interference capabilities for their detection. In this work, two {PMoO}-based compounds, [H(HPTTP)]{Cu[MoO(OH)(PO)(HPO)(HPO)]}·HO ( = 13 for (), 7 for (); HPTTP = 4,4',4″,4‴-(1-pyrrole-2,3,4,5-tetrayl)tetrapyridine), exhibiting similar coordination but distinct stacking modes.
View Article and Find Full Text PDFSwin-cryoEM: Multi-class cryo-electron micrographs single particle mixed detection method.
PLoS One
April 2024
School of Geography and Information Engineering, China University of Geosciences (Wuhan), Wuhan, Hubei, China.
Cryo-electron micrograph images have various characteristics such as varying sizes, shapes, and distribution densities of individual particles, severe background noise, high levels of impurities, irregular shapes, blurred edges, and similar color to the background. How to demonstrate good adaptability in the field of image vision by picking up single particles from multiple types of cryo-electron micrographs is currently a challenge in the field of cryo-electron micrographs. This paper combines the characteristics of the MixUp hybrid enhancement algorithm, enhances the image feature information in the pre-processing stage, builds a feature perception network based on the channel self-attention mechanism in the forward network of the Swin Transformer model network, achieving adaptive adjustment of self-attention mechanism between different single particles, increasing the network's tolerance to noise, Incorporating PReLU activation function to enhance information exchange between pixel blocks of different single particles, and combining the Cross-Entropy function with the softmax function to construct a classification network based on Swin Transformer suitable for cryo-electron micrograph single particle detection model (Swin-cryoEM), achieving mixed detection of multiple types of single particles.
View Article and Find Full Text PDFPrevalence and molecular characterization of Giardia duodenalis in dairy cattle in Central Inner Mongolia, Northern China.
Sci Rep
August 2023
College of Veterinary Medicine, Inner Mongolia Agricultural University, Hohhot, China.
Article Synopsis
- The study focused on the prevalence and genetic diversity of the Giardia duodenalis protozoan in dairy cattle in Central Inner Mongolia, highlighting the potential risk of giardiasis transmission to humans, particularly from cattle.
- Researchers analyzed 505 fecal samples from dairy cows, revealing a G. duodenalis prevalence of 29.5%, with higher rates in diarrheal samples, though results were statistically insignificant.
- The majority of detected parasites belonged to assemblage E, with findings indicating a diverse range of multilocus genotypes, marking this as the first report of G. duodenalis infection in dairy cattle in this region.
Prevalence and molecular characterization of Cryptosporidium spp. in dairy cattle in Central Inner Mongolia, Northern China.
BMC Vet Res
August 2023
College of Veterinary Medicine, Inner Mongolia Agricultural University, Hohhot, China.
Article Synopsis
- Cryptosporidium is a protozoan pathogen found in cattle, leading to human gastrointestinal illness; this study examines its prevalence in dairy cattle in Central Inner Mongolia.
- Out of 505 manure samples, 29.90% tested positive for Cryptosporidium, with the highest rates in diarrheal samples (37.67%), and four species were identified, mainly C. bovis and C. andersoni.
- The study provides new insights on Cryptosporidium distribution in dairy cattle, marking a significant contribution to understanding its impact on public health and zoonotic transmission.
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