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Quantitative annotations of T-Cell repertoire specificity.
Brief Bioinform
May 2023
Department of Computer Science, City University of Hong Kong, 83 Tat Tree Ave, Kowloon Tong, Hong Kong, China.
The specificity of a T-cell receptor (TCR) repertoire determines personalized immune capacity. Existing methods have modeled the qualitative aspects of TCR specificity, while the quantitative aspects remained unaddressed. We developed a package, TCRanno, to quantify the specificity of TCR repertoires.
View Article and Find Full Text PDFRecurrent congenital cytomegalovirus infection in a sequential pregnancy with severe sequelae, and a possible association with prophylactic valacyclovir treatment: a case report.
Int J Infect Dis
December 2022
Central Virology Laboratory, Ministry of Health, Tel Hashomer, Israel. Electronic address:
Recurrent congenital cytomegalovirus infections in consecutive pregnancies are rarely reported. Due to the risk of fetal infection from preconception maternal infection, a 6-month interval after primary maternal infection is generally advised before a new conception. Recently, high-dose valacyclovir treatment was shown to prevent fetal infection in first trimester primary infections.
View Article and Find Full Text PDFArticle Synopsis
- CMV infection is a significant concern after allogeneic hematopoietic stem cell transplantation (HSCT) since T cell responses that help fight the virus are weakened during the procedure.
- Adoptive T cell therapy (ACT) aims to enhance immune responses by transferring CMV-specific T cells from an immune donor to the transplant recipient, improving their ability to combat the virus.
- Despite its potential, challenges like HLA restrictions, long manufacturing times, and donor availability have limited the widespread use of ACT, although new genetic engineering techniques are emerging to enhance T cell effectiveness against CMV post-transplant.
Evaluation of T-activated proteins as recall antigens to monitor Epstein-Barr virus and human cytomegalovirus-specific T cells in a clinical trial setting.
J Transl Med
June 2020
Institute of Virology, Helmholtz Zentrum München/Technical University of Munich, School of Medicine, Schneckenburgerstr. 8, 81675, Munich, Germany.
Background: Pools of overlapping synthetic peptides are routinely used for ex vivo monitoring of antigen-specific T-cell responses. However, it is rather unlikely that these peptides match those resulting from naturally processed antigens. T-activated proteins have been described as immunogenic and more natural stimulants, since they have to pass through antigen processing and comprise activation of all clinically relevant effector cell populations.
View Article and Find Full Text PDFAltered Repertoire Diversity and Disease-Associated Clonal Expansions Revealed by T Cell Receptor Immunosequencing in Ankylosing Spondylitis Patients.
Arthritis Rheumatol
August 2020
Queensland University of Technology and Translational Research Institute, Brisbane, Queensland, Australia, and Guy's and St Thomas' NHS Foundation Trust and King's College London NIHR Biomedical Research Centre, King's College London, UK.
Objective: Ankylosing spondylitis (AS) is a common spondyloarthropathy primarily affecting the axial skeleton and strongly associated with HLA-B*27 carriage. Genetic evidence implicates both autoinflammatory processes and autoimmunity against an HLA-B*27-restricted autoantigen in immunopathology. In addition to articular symptoms, up to 70% of AS patients present with concurrent bowel inflammation, suggesting that adverse interactions between a genetically primed host immune system and the gut microbiome contribute to the disease.
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