AI Article Synopsis
- Myoglobinuria, the presence of myoglobin in urine, can be challenging to diagnose and is associated with various systemic and neurological disorders.
- A case study of a 23-year-old man revealed recurrent myoglobinuria linked to necrotizing vacuolar myopathy, confirmed by muscle biopsy, which showed atypical histopathological findings.
- Effective management of recurrent myoglobinuria is crucial to prevent renal dysfunction and further symptoms, particularly when no toxins, drugs, or seizures are involved, indicating a primary muscle disease.
Article Abstract
Myoglobinuria occurs in a variety of systemic and neurological disorders and can pose diagnostic challenges. We report on a 23-year-old man in whom recurrent myoglobinuria was observed due to necrotizing vacuolar myopathy confirmed on muscle biopsy. Histopathologically the intramuscular vacuoles lacked the typical findings reported in vacuolar myopathy due to disorders of glycogen and lipid metabolism. We discuss the management approach to recurrent myoglobinuria. Recurrent myoglobinuria in the absence of toxin or drug exposure and seizure is more often due to primary muscle disease. Recognizing the presence of myoglobinuria and the proximate cause is essential in preventing the development of renal dysfunction and the future recurrence of symptoms.
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| http://dx.doi.org/10.3109/00207454.2010.518778 | DOI Listing |
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