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Leptospirosis with Indian Tick-borne Typhus Coinfection: A Rare Presentation of Tropical Febrile Illness.
J Assoc Physicians India
October 2024
Professor, Department of Microbiology, Parul Institute of Medical Sciences and Research, Parul University, Waghodia, Gujarat, India.
Article Synopsis
- Leptospirosis and tick-borne typhus are zoonotic diseases that are rarely seen together, leading to challenges in diagnosis and treatment.
- A case involving an abattoir worker presented symptoms like fever, jaundice, and renal failure, eventually diagnosed with both infections through various lab tests.
- This case highlights the importance of timely and accurate diagnosis for effective treatment of these rare coinfections to prevent severe health complications.
Usefulness of next-generation sequencing for laboratory diagnosis of rickettsiosis.
PLoS Negl Trop Dis
October 2024
Department of Microbiology, School of Clinical Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong, China.
Article Synopsis
- - The study examined six patients diagnosed with various rickettsiosis infections using metagenomic next-generation sequencing (mNGS), which can be challenging for traditional laboratory diagnostics.
- - One patient with Japanese spotted fever was quickly diagnosed through mNGS, while two others with Rickettsia felis infections showed the bacterium in lung samples; both patients were immunocompromised due to cancer treatments.
- - Three additional patients, presenting with fever and eschar, had negative Weil-Felix test results, but mNGS confirmed the presence of Orientia tsutsugamushi, indicating scrub typhus; this highlights mNGS as a vital tool alongside serology for diagnosing rickettsiosis.
Sero-evidence of Rickettsia Infection by ELISA in the Northern-Central Area of Bangladesh.
Mymensingh Med J
October 2024
Dr Faria Ferdouse, Associate Professor, Department of Microbiology, Shaheed Monsur Ali Medical College (SMAMC), Dhaka, Bangladesh; E-mail:
Detection of rickettsia most commonly done by simple, economical Weil-Felix test which detects IgM antibody. This initial investigation provides limited sound guidance to clinical decisions because of its low specificity and sensitivity. An alternative test, enzyme-linked immunosorbent assay (ELISA) is faster, less complicated, can also be automated.
View Article and Find Full Text PDFJapanese spotted fever in an area endemic to SFTS virus: Case report and review of the literature.
Medicine (Baltimore)
August 2024
Department of Infectious Diseases, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.
Article Synopsis
- The spread of Japanese spotted fever (JSF) in China is increasing, especially in regions with high cases of severe fever with thrombocytopenia syndrome (SFTS), complicating diagnosis due to shared symptoms and low awareness among healthcare providers.
- All three patients initially misdiagnosed with SFTS had fieldwork history and presented cold-like symptoms, lymph node enlargement, and unique rashes, but were later correctly diagnosed with JSF after advanced testing.
- Treatment with doxycycline led to rapid symptom improvement and normal lab results, highlighting the importance of distinguishing between JSF and SFTS through specific clinical indicators.
A Clinical Study of Rickettsial Fever and Factors Affecting Its Outcome.
Cureus
July 2024
Medicine, Dr. D. Y. Patil Medical College, Hospital and Research Centre, Pune, IND.
Introduction: Rickettsiae comprise a family of obligate intracellular short gram-negative coco-bacilli and are transmitted by insects, mites, fleas, louse, and tick vectors. Scrub typhus, north-Asian tick typhus, rickettsia pox, and boutonniere fevers are common in India and Asia. In the early phase of illness during the initial five days, all these are indistinguishable among themselves; also, they mimic any other self-limiting viral fever.
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