Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1038/ja.2010.111 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Marine actinomycetes-derived angucyclines and angucyclinones with biosynthesis and activity--past 10 years (2014-2023).
Eur J Med Chem
February 2025
The Affiliated Hospital of Qingdao University, Qingdao University, Qingdao, 266000, China; Institute of Regenerative Medicine and Laboratory Technology Innovation, Qingdao University, Qingdao, Shandong, 266071, China. Electronic address:
Actinomycete bacteria derived from marine environments are a good source of natural products with diverse biological activities such as cytotoxicity, antiviral, and antimicrobial actions. This review summarizes 191 angucyclines and angucyclinones derived from marine actinomycetes reported in the literature from 2014 to 2023 and introduced the latest developments in actinomycete-silenced biosynthetic gene cluster activation, including heterologous recombination and in situ activation. The key role of redox post-modifications in the biosynthetic process of atypical angucyclines.
View Article and Find Full Text PDFCo-expression of a pair of interdependent regulators coding genes ovmZ and ovmW awakens the production of angucyclinones antibiotics in Streptomyces neyagawaensis.
Microb Cell Fact
July 2024
State Key Laboratory of Microbial Resources, Institute of Microbiology, Chinese Academy of Sciences, Beijing, 100101, China.
Article Synopsis
- Researchers discovered that activating specific gene clusters (BGCs) in streptomycetes can lead to the production of new compounds, revealing many silent biosynthetic potential.* -
- The study identified that two related genes, ovmZ and ovmW, are crucial for activating these silent BGCs, allowing the production of compounds like gephyromycin A when both genes are overexpressed in Streptomyces neyagawaensis.* -
- The findings suggest that co-overexpression of ovmZ and ovmW could be a promising method for stimulating the production of secondary metabolites across various actinobacteria.*
The Chemistry of Angucyclines.
Chempluschem
October 2024
Department of Organic Chemistry, Faculty of Science, Palacký University Olomouc, 17. listopadu 1192/12, 779 00, Olomouc, Czech Republic.
Angucyclines and angucyclinones represent a class of natural compounds that belong to the group of aromatic polyketides. They exhibit a wide array of biological properties, such as antimicrobial, antiviral, and cytotoxic. Their considerable therapeutic potential and diverse scaffolds have attracted many synthetic chemists to devise novel strategies to construct their intricate molecular architecture.
View Article and Find Full Text PDFMetabolic Blockade-Based Genome Mining of Sea Anemone-Associated sp. S1502 Identifies Atypical Angucyclines WS-5995 A-E: Isolation, Identification, Biosynthetic Investigation, and Bioactivities.
Mar Drugs
April 2024
CAS Key Laboratory of Tropical Marine Bio-Resources and Ecology, RNAM Center for Marine Microbiology, Guangdong Key Laboratory of Marine Materia Medica, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Haizhu District, Guangzhou 510301, China.
Marine symbiotic and epiphyte microorganisms are sources of bioactive or structurally novel natural products. Metabolic blockade-based genome mining has been proven to be an effective strategy to accelerate the discovery of natural products from both terrestrial and marine microorganisms. Here, the metabolic blockade-based genome mining strategy was applied to the discovery of other metabolites in a sea anemone-associated sp.
View Article and Find Full Text PDFMultifactorial genetic control and magnesium levels govern the production of a antibiotic with unusual cell density dependence.
mSystems
April 2024
Institute of Infectious Disease Research and Department of Biology, McMaster University, Hamilton, Ontario, Canada.
bacteria are renowned both for their antibiotic production capabilities and for their cryptic metabolic potential. Their metabolic repertoire is subject to stringent genetic control, with many of the associated biosynthetic gene clusters being repressed by the conserved nucleoid-associated protein Lsr2. In an effort to stimulate new antibiotic production in wild isolates, we leveraged the activity of an Lsr2 knockdown construct and successfully enhanced antibiotic production in the wild isolate WAC07094.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!