Beclin 1 is a protein involved in the regulation of autophagy and has been shown to be reduced in patients with Alzheimer disease. This review summarizes the current research data that link disturbances in autophagy, a cellular degradation and maintenance pathway, to the development of Alzheimer disease and related neurodegenerative diseases. It also provides a brief overview of the existing pharmacological interventions available to modulate autophagy activity in mammalian cells.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1001/archneurol.2010.258 | DOI Listing |
Publication Analysis
Top Keywords
alzheimer disease
12
beclin complex
4
autophagy
4
complex autophagy
4
autophagy alzheimer
4
disease beclin
4
beclin protein
4
protein involved
4
involved regulation
4
regulation autophagy
4
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!