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Comparative Efficacy of Azithromycin and Clarithromycin in the Management of Helicobacter pylori Infection.
Cureus
October 2024
Gastroenterology and Hepatology, Jordanian Royal Medical Services, Amman, JOR.
Aim: In this study, the main goal was to find a statistically significant difference between eradication treatment plans that used azithromycin and clarithromycin in triple and quadruple eradication plans.
Methods: This retrospective, single-center, observational, non-funded Helicobacter pylori management study examined patients who visited our institutional gastroenterology clinic at the King Hussein Medical Centre in the Royal Medical Services, Amman, Jordan, from January 2023 to May 2024. The most common treatment (TRT) courses are 7 or 10-14 days, so this study divided the therapy length into two categories.
Comparative Efficacy and Safety of Potassium-Competitive Acid Blockers and Proton Pump Inhibitors for First-Line Helicobacter pylori Eradication Therapy: A Systematic Review and Network Meta-Analysis.
Helicobacter
November 2024
Department of Pharmacy, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Background: Given the increasing antibiotic resistance and the inadequate acid-suppressing effects of proton pump inhibitors (PPIs), it is crucial to continuously optimize existing Helicobacter pylori (H. pylori) treatment regimens. This study aimed to evaluate the clinical efficacy and safety of novel potassium-competitive acid blocker (P-CAB)-based eradication regimens compared with traditional PPI-based regimens for the initial treatment of H.
View Article and Find Full Text PDFEvolution of the use, effectiveness and safety of bismuth-containing quadruple therapy for infection between 2013 and 2021: results from the European registry on management (Hp-EuReg).
Gut
December 2024
Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), Instituto de Salud Carlos III, Madrid, Spain.
Article Synopsis
- Bismuth quadruple therapies (BQTs) have been effective in treating Helicobacter pylori infections in Europe, particularly in the face of antibiotic resistance, with notable use increasing from 8.6% in 2013 to 39% in 2021.
- An analysis of data from nearly 50,000 patients indicated that the single-capsule BQT was the most common regimen and achieved over 90% effectiveness with certain combinations.
- Key factors that improved treatment success included adherence to the regimen, use of high-dose proton pump inhibitors, and implementing the therapy as a first-line treatment.
Pattern of Prescribing Proton Pump Inhibitors: Evaluating Appropriateness and Factors Contributing to Their Adverse Effect Reaction Risk.
J Clin Med
October 2024
Departments of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE 68198, USA.
: Proton pump inhibitors (PPIs) are amongst the most commonly prescribed classes of medication. However, inappropriate PPI use can lead to several adverse drug reactions (ADRs). Limited data exist on factors contributing to the risk of ADRs associated with PPI prescribing patterns in the Eastern Region of Saudi Arabia.
View Article and Find Full Text PDF[Prophylaxis with proton pump inhibitors in case of corticosteroid therapy: "less is more"].
Rev Med Suisse
October 2024
Service de médecine interne et générale, Département de médecine, Hôpitaux universitaires de Genève, 1211 Genève 14.
It is common to routinely prescribe gastric ulcer prophylaxis with proton pump inhibitors (PPIs) when administering high-dose glucocorticoids (GC) (> 30 mg/day of prednisone equivalent) or during prolonged time (> 15 days). This routine is due to a risk profile considered safe for PPIs in comparison to the possible severe consequences of developing a gastric ulcer. Given the numerous adverse effects associated with PPIs, it is preferable to question the risk-benefit balance when prescribing them.
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