Bioprecursor prodrugs: molecular modification of the active principle.

Mini Rev Med Chem

Department of Pharmaceutical Chemistry, Sinhgad Institute of Pharmaceutical Sciences, Kusgaon (Bk.), Lonavala, Pune, Maharashtra, India-410401.

Published: December 2010

A large number of therapeutic medications have undesirable properties that may generate pharmacological, pharmaceutical, or pharmacokinetic barriers in clinical drug applications. Metabolism of drugs by Phase-I & Phase-II metabolic pathways for possibility of active metabolites, which could in turn useful for rational designing of bioprecursor prodrugs of the active principle of interest. This review summarizes various approaches & development of drugs, namely bioprecursor prodrugs and active metabolites related to bioprecursor prodrugs.

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http://dx.doi.org/10.2174/138955710793564179DOI Listing

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