AI Article Synopsis
- The study aimed to assess the impact of high-volume hemofiltration treatment (HVHF) on lactic acid, pro-inflammatory cytokines, and C-reactive protein levels in patients with severe sepsis.
- Thirty patients diagnosed with severe sepsis received HVHF treatment, with measurements taken for various biomarkers before and at subsequent hours post-treatment.
- Results showed a significant decrease in lactic acid and IL-6 levels after HVHF, suggesting that early HVHF can enhance tissue oxygenation and reduce inflammation in severe sepsis cases.
Article Abstract
Objective: To evaluate the effect of early application of high-volume hemofiltration treatment (HVHF) on the levels of lactic acid, pro-inflammatory cytokines and C-reactive protein (CRP) in plasma, as well as APACHE II score in patients suffering from severe sepsis.
Methods: Thirty patients meeting the diagnosis of severe sepsis were enrolled in the trial within 24 hours of insults. The level of lactic acid, interleukin-6 (IL-6) and CRP in plasma were measured before HVHF and at 24, 48 or 72 h following HVHF treatment.
Result: The plasma levels of lactic acid and IL-6 decreased significantly at 24 h, 48 h, 72 h after HVHF (P <0.05), while, IL-10 did not differ significantly following HVHF (P>0.05), when compared with that before HVHF.
Conclusion: The early application of HVHF could clear the plasma lactic acid and pro-inflammatory cytokines, and improve the tissue oxygenation in severe sepsis.
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| http://dx.doi.org/10.3785/j.issn.1008-9292.2010.05.007 | DOI Listing |
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