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Schiff bases targeting an Sw-480 colorectal cell line: synthesis, characterization, ds-DNA binding and anticancer studies.
RSC Adv
January 2025
Centre for Genetics and Inherited Diseases (CGID), Taibah University Madinah Saudi Arabia.
In present studies, six Schiff bases were prepared, characterized and evaluated for their anti-tumor activity against the colorectal cancer cell line SW-480. The test compounds were characterized by various physico-chemical techniques such as M. P.
View Article and Find Full Text PDFNew lanthanum (III) complexes containing azaphosphor β-diketon and diimine ligands: Synthesis, crystallography, morphology properties, DNA binding, DNA cleavage, and DFT calculation.
Int J Biol Macromol
December 2024
Faculty of Chemistry and Mineralogy, Universität Leipzig, Johannisallee 29, Leipzig 04103, Germany.
Two octa-coordinated lanthanum (III) complexes of deprotonated azaphosphor β-diketon and diimine ligands, [LnLQ] (L = [ClCHC(O)NP(O)(NCH)], Q = Phen (C1) and Bipy (C2)), were synthesized and characterized by elemental analysis, IR, and NMR spectra. X-ray crystallography revealed a distorted tetragonal antiprism LaO6N2 coordination geometry around the lanthanum atom in both compounds. Nano-sized complexes (Ć1 and Ć2) were synthesized via a sonochemical process and analyzed using SEM and XRPD.
View Article and Find Full Text PDFDNA or not DNA -that is the question determining the design of platinum anticancer drugs.
Eur J Med Chem
January 2025
State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing, 210023, PR China. Electronic address:
Platinum drugs are the most widely used chemotherapeutics to treat various tumors. Their primary mode of action is supposed to be inducing apoptosis of cancer cells via covalent binding to DNA. This mechanism has shackled the design of new platinum drugs for many years.
View Article and Find Full Text PDFThe Intercalator Ethidium Bromide Generates Covalent Adducts at Apurinic/Apyrimidinic Sites in DNA.
Chem Res Toxicol
November 2024
Department of Chemistry, University of Missouri, 125 Chemistry Building, Columbia, Missouri 65211, United States.
Ethidium bromide was first described as a DNA intercalator 60 years ago and, over the ensuing years, may be the most widely used fluorescent DNA stain in molecular biology, biochemistry, and histology. Noncovalent DNA binding by ethidium has been well characterized, but to date, there have been no reports of covalent DNA adduct formation by ethidium bromide. This report describes the characterization of covalent adducts generated by the reaction of ethidium with apurinic/apyrimidinic (AP) sites in DNA.
View Article and Find Full Text PDFTsg101 UEV Interaction with Nedd4 HECT Relieves E3 Ligase Auto-Inhibition, Promoting HIV-1 Assembly and CA-SP1 Maturation Cleavage.
Viruses
October 2024
Department of Microbiology & Immunology, Renaissance School of Medicine, Stony Brook University, Stony Brook, NY 11794, USA.
Article Synopsis
- Tsg101 is a protein critical for cellular processes related to transport, specifically involved in recognizing tagged proteins and recruiting other necessary components for transport, particularly during virus budding.* -
- The study highlights how Tsg101 interacts with ubiquitin (Ub) ligases (E3 enzymes), revealing that disrupting a specific motif in Tsg101 shifts the budding process’s dependency to another ligase, Nedd4L, showing the intricate interplay between these proteins.* -
- Small molecule experiments showed that disrupting Tsg101’s ability to bind Ub or Nedd4 halted viral budding early in the process, emphasizing Tsg101's role in regulating E3 ligases and its importance in viral particle assembly and overall cellular functions.*
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