Epilepsy affects an estimated 60 million people worldwide. As many as 50% of people with epilepsy will continue to have seizures despite therapeutic dosages of appropriately selected antiepileptic drugs. Among proposed treatment modalities for persons with medication refractory epilepsy are implantable devices that rapidly detect and abort seizures. Computational resources in these devices are limited and much effort is directed to improving the efficiency of seizure detection. The goal of this study is to determine if electroencephalogram (EEG) may be reduced by the method of natural position order in a way that increases computation speed and reduces system memory requirements while preserving features relevant to detecting seizure onset. In this study we show increased mutual information (MI) at seizure onset in simultaneous channels of EEG reduced by natural position order with a 40-fold reduction in computation time and a fivefold reduction in system memory requirements. The trade-offs to EEG reduction by natural position order include decreased bandwidth and increased noise sensitivity.
Autumn leaf colour brightness is an important cultural ecosystem service. As its spatial patterns and ecophysiological mechanisms remain unclear, we analysed relationships among autumn leaf colour brightness, late summer chlorophyll content, and topographic position in both canopy-based micro-scale analysis and site-based macro-scale analysis. Multispectral drone observations were made in three Fagus crenata forests at elevations of 300, 600, and 900 m in Niigata Prefecture, Japan.
Department of Biological and Environmental Sciences, Faculty of Natural Sciences, Walter Sisulu University, Nelson Mandela Drive Campus, P/Bag X1, Mthatha 5117, Eastern Cape, South Africa.
Invertebrates form a vital component of agricultural ecosystems, and they are chief actors in sustaining the functions of the ecosystem and soil health. Scholarly publications that concentrated on visualizing the research outputs and trends on invertebrates and agriculture are scarce. In this paper, we adopted a bibliometric model to extract trends/research studies on invertebrates and agriculture between 1991 and 2022, using scholarly studies retrieved from the Web of Science (WoS) databank.
Department of Chemistry, Wuhan University, Wuhan, 430072, China; School of Bioengineering and Health, Wuhan Textile University, Wuhan, 430200, China; Frontier Science Center for Immunology and Metabolism, Wuhan University, Wuhan, 430071, China. Electronic address:
Branched fatty acid esters of hydroxy fatty acids (FAHFAs) represent a novel class of bioactive lipids with significant physiological roles. However, their identification, particularly of low-abundance FAHFA regioisomers, remains challenging due to their high structural similarity, low natural abundance, and the limited availability of reliable FAHFA standards. In this study, we present a QSAR-based FAHFA annotation strategy that integrates a QSAR model with an ester bond position (EP) rule to determine the EPs of FAHFA regioisomers.
Background: Malaria remains a threat in sub-Saharan Africa, particularly in Côte d'Ivoire, where it is endemic and represents the leading cause of hospital consultations, morbidity and mortality. The strong climatic variations that exist between coastal and savannah areas of Côte d'Ivoire suggest that vector control interventions should be scheduled according to the eco-epidemiological diversity. This study evaluates bioecological parameters of vectors and malaria transmission in two health districts, one coastal and one central of Côte d'Ivoire.
Laboratory Medicine Center, Department of Genetic and Genomic Medicine, Zhejiang Provincial People's Hospital, Affiliated People's Hospital, Hangzhou Medical College, Hangzhou, Zhejiang, China.
Background: GTPBP3 catalyzes τm(s) U biosynthesis at the 34th wobble position of mitochondrial tRNAs, the hypomodification of τmU leads to mitochondrial disease. While twenty-three variants of GTPBP3 have been reported worldwide, the genetic landscape in China remains uncertain.
Methods: By using whole-exome sequencing, the candidate individuals carrying GTPBP3 variants were screened and identified.
