The Mukaiyama aldol-Prins (MAP) cyclization of acetals stereoselectively provided substituted tetrahydropyrans. The scope of the reaction has been expanded to include other electrophiles, including ketals and α-acetoxy ethers. Finally, a double MAP cyclization with orthoformates is described.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2951841 | PMC |
| http://dx.doi.org/10.1055/s-2008-1032053 | DOI Listing |
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