AI Article Synopsis
- The study presents 16 newly synthesized mefloquine derivatives created by reacting mefloquine with benzaldehydes.
- These derivatives showed meaningful antitubercular activity with a minimum inhibitory concentration (MIC) of 12.6 μM.
- Importantly, the compounds were non-cytotoxic, indicating their potential for developing new anti-TB treatments.
Article Abstract
In this work, we report the synthesis and the antitubercular evaluation of 16 new mefloquine derivatives, formed from reactions between mefloquine and benzaldehydes, with the activity expressed as the minimum inhibitory concentration (MIC) in μM. The compounds were non-cytotoxic and exhibited an important activity (12.6 μM). The appreciable activity of these compounds can be considered an important finding for the rational design of new leads for anti-TB compounds.
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| http://dx.doi.org/10.1016/j.ejmech.2010.09.024 | DOI Listing |
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