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The effect of neoadjuvant chemotherapy on survival outcomes in patients with variant histologies who underwent radical cystectomy with precystectomy diagnostic accuracy: A multicenter study of the Turkish Urooncology Association.
Int J Urol
January 2025
Department of Urology, School of Medicine, Ankara University, Ankara, Turkey.
Objectives: To evaluate the role of neoadjuvant chemotherapy in the final treatment plan and its impact on survival in bladder cancer patients who were diagnosed with variant histology in the radical cystectomy specimen and whose diagnostic accuracy was achieved with the previous transurethral resection of the bladder specimen.
Methods: In this retrospective multicenter study, data from 221 patients across 9 centers were analyzed between January 2012 and January 2022. The primary endpoint was overall, cancer-specific, recurrence-free, and metastasis-free survival rates among patients with and without neoadjuvant chemotherapy, and the secondary endpoint was to identify independent predictors of survival.
A Pressing Emergency in Oncology: A Case Series of Patients With Posterior Reversible Encephalopathy Syndrome.
Cureus
December 2024
Department of General Medicine, Vydehi Institute of Medical Sciences and Research Centre, Bangalore, IND.
Background: The defining characteristic of posterior reversible encephalopathy syndrome (PRES) is a reversible, predominantly vasogenic edema of the white matter, particularly affecting the parenchyma supplied by the posterior circulation. PRES is most commonly associated with hypertension. We present a case series of seven normotensive patients diagnosed with cancer who had posterior reversible encephalopathy syndrome.
View Article and Find Full Text PDFThe role of body composition in neurological and hematologic toxicity in a retrospective analysis of 120 breast cancer patients undergoing neoadjuvant chemotherapy: the COMBOTOX study.
Breast Cancer Res Treat
December 2024
Breast Unit, Department of Women, Children and Public Health Sciences, Fondazione Policlinico Universitario "A. Gemelli" IRCCS, Largo Agostino Gemelli, 8, 00136, Rome, Italy.
Purpose: Neoadjuvant chemotherapy (NAC) has a well-established role in locally advanced or chemoresponsive breast cancers (BC). Chemotherapic regimens are effective when patients receive the optimal doses. Toxicities are common in overweight/obese patients but may occur also in normal weight counterparts.
View Article and Find Full Text PDFSuccessful management of type B lactic acidosis in metastatic cervical neuroendocrine carcinoma: A case report.
Oncol Lett
February 2025
Department of Oncology, People's Liberation Army General Hospital of Western Theater Command, Chengdu, Sichuan 610083, P.R. China.
Article Synopsis
- Type B lactic acidosis is a serious condition linked to certain cancers, particularly in blood-related cancers, and this case focuses on a 59-year-old woman with metastatic cervical neuroendocrine carcinoma who experienced severe symptoms and high lactate levels.
- Initial treatments like fluid replacement and sodium bicarbonate didn't work, leading to the administration of a lower dose of etoposide chemotherapy, which resulted in tumor lysis syndrome that was managed effectively.
- After chemotherapy, the patient's lactate levels dropped significantly, and her condition improved enough for her to be discharged, showcasing a potential treatment approach for malignancy-associated lactic acidosis and emphasizing the need for careful management of related complications.
Definite Treatment Delay With Neoadjuvant Chemotherapy and Longitudinal Monitoring by Circulating Tumor DNA for Advanced Cervical Cancer During Pregnancy: A Case Series and Literature Review.
Cancer Rep (Hoboken)
November 2024
Department of Obstetrics and Gynecology, Zhongda Hospital, Southeast University, Nanjing, China.
Background: Previous studies mainly concentrate on neoadjuvant chemotherapy (NACT) for delivery delay in FIGO Stage IB1-IIIB cervical cancer during pregnancy to prevent early preterm delivery while not affecting maternal outcome.
Case: Here, we described two pregnant patients with FIGO Stage IIIC cervical cancer about their diagnosis, treatment, and outcome. Both patients underwent cesarean delivery, left enlarged lymph node dissection, and longitudinal monitoring by circulating tumor DNA.
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