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Understanding Perceptions of Hepatitis C and Its Management Among People with Experience of Incarceration in Quebec, Canada: A Qualitative Study Guided by the Common Sense Self-Regulation Model.
Viruses
December 2024
Centre for Outcomes Research and Evaluation, Research Institute of the McGill University Health Centre, Montreal, Canada.
Hepatitis C virus (HCV) disproportionately affects certain sub-populations, including people with experience of incarceration (PWEI). Little is known about how perceptions of HCV and treatment have changed despite simplifications in testing and treatment in carceral settings. Nineteen semi-structured interviews were conducted with people living with or having a history of HCV infection released from Quebec provincial prison.
View Article and Find Full Text PDFThe Influence of Diet and Obesity in Lynch Syndrome: What Do We Know So Far.
Nutrients
December 2024
Laboratório Associado, Escola Superior de Biotecnologia, Centro de Biotecnologia e Química Fina, Universidade Católica Portuguesa, CBQF, Rua Diogo Botelho 1327, 4169-005 Porto, Portugal.
Of all new cases of colorectal cancer, Lynch syndrome (LS) accounts for approximately 3%. This syndrome is the most common hereditary cancer syndrome and is caused by pathogenic variants in the genes responsible for DNA mismatch repair. Although the relationship between colorectal cancer risk and diet is well established, little is known regarding the influence of diet and nutritional characteristics on LS's clinical evolution.
View Article and Find Full Text PDFAssociation of TyG Index and TG/HDL-C Ratio with Trajectories of Depressive Symptoms: Evidence from China Health and Retirement Longitudinal Study.
Nutrients
December 2024
Department of Medical Statistics, School of Public Health, Sun Yat-sen University, 74 Zhongshan Second Rd, Guangzhou 510080, China.
Objectives: To explore whether the triglyceride-glucose (TyG) index and the triglyceride to high-density lipoprotein cholesterol (TG/HDL-C) ratio are associated with the trajectories of depressive symptoms.
Methods: In this longitudinal study, 4215 participants aged 45 years and older were recruited from the China Health and Retirement Longitudinal Study from 2011 to 2018. The trajectories of depressive symptoms, measured by the 10-item Center for Epidemiologic Studies Depression Scale (CESD-10), were identified using group-based trajectory modeling.
A Modified Multiaxial Fatigue Model and Its Application for the Fatigue Life Prediction of Aircraft Hydraulic Pipes.
Materials (Basel)
December 2024
School of Mechatronic Engineering, Xidian University, No. 2 South Taibai Road, Xi'an 710071, China.
The fatigue failure of a structure may occur under a multiaxial vibration environment; it is necessary to establish a better multiaxial fatigue life prediction model to predict the fatigue life of the structure. This study proposes a new model (MWYT) by introducing the maximum absolute shear stress into the WYT model. The feasibility of the MWYT model is verified by using the multiaxial fatigue experimental data of 304 stainless steel, Q235B steel, 7075-T651 aluminum alloy and S355J0 steel.
View Article and Find Full Text PDFBichromatic Splicing Detector Allows Quantification of and Splicing Isoforms in Single Cells by Fluorescent Live-Cell Imaging.
Int J Mol Sci
December 2024
Department of Neuropediatrics, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität Berlin, and Berlin Institute of Health, 13353 Berlin, Germany.
Thyroid hormone receptor alpha (THR) is a nuclear hormone receptor that binds triiodothyronine (T3) and acts as an important transcription factor in development, metabolism, and reproduction. The coding gene, , has two major splicing isoforms in mammals, and , which encode THR1 and THR1, respectively. The better characterized isoform, THR1, is a transcriptional stimulator of genes involved in cell metabolism and growth.
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