AI Article Synopsis
- Lymphoid tissue-inducer (LTi) cells play a crucial role in developing lymphoid tissues by activating local stromal cells, similar to how inflammation works.
- These cells express the nuclear hormone receptor RORγt, which also influences the production of interleukin-17 in T cells, connecting them to proinflammatory responses.
- RORγt(+) innate lymphoid cells (ILCs) are derived from specific fetal liver precursors, and their development is age-dependent, shifting post-birth towards supporting intestinal health and defense, even in the absence of microbiota.
Article Abstract
Lymphoid tissue-inducer (LTi) cells initiate the development of lymphoid tissues through the activation of local stromal cells in a process similar to inflammation. LTi cells express the nuclear hormone receptor RORγt, which also directs the expression of the proinflammatory cytokine interleukin-17 in T cells. We show here that LTi cells are part of a larger family of proinflammatory RORγt(+) innate lymphoid cells (ILCs) that differentiate from distinct fetal liver RORγt(+) precursors. The fate of RORγt(+) ILCs is determined by mouse age, and after birth, favors the generation of cells involved in intestinal homeostasis and defense. Contrary to RORγt(+) T cells, however, RORγt(+) ILCs develop in the absence of microbiota. Our study indicates that RORγt(+) ILCs evolve to preempt intestinal colonization by microbial symbionts.
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| http://dx.doi.org/10.1126/science.1194597 | DOI Listing |
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