A method of thin layer chromatographic separation and ultraviolet spectrophotometric determination of tangshenoside I in Codonopsis pilosula is described. A comparison of the contents in various samples is made. The contents of tangshenoside I in frosted sample have been found to be twice as much as in normal drug. The recovery of tangshenoside I is 99.92% and the coefficient of variation of eight samplings is 1.77%.
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Plants (Basel)
November 2024
School of Pharmacy, Sungkyunkwan University, Suwon 16419, Republic of Korea.
, commonly known as the bonnet bellflower or deodeok, is primarily found in Eastern Asia. Its roots have been used traditionally across Asia to treat various ailments such as bronchitis, coughs, asthma, and inflammation. In our ongoing efforts to discover bioactive natural products, a phytochemical investigation of the -BuOH fraction of root extracts led to the isolation and identification of a new indole alkaloid -glycoside, deodeokaloid (D-indole-3-lactic acid -β-D-glucopyranoside) (), alongside known compounds tangshenoside I (), tangshenoside IV (), and chlorogenic acid () through HPLC purification.
View Article and Find Full Text PDFJ Ethnopharmacol
January 2025
Department of Drug Metabolism, Beijing Key Laboratory of Non-Clinical Drug Metabolism and PK/PD Study, State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, 100050, Beijing, PR China. Electronic address:
Ethnopharmacological Relevance: Codonopsis pilosula (C. pilosula), commonly known as Dangshen in Chinese, had been used to regulate the immune, digestive, and circulatory systems of human. The reported pharmacokinetic studies on C.
View Article and Find Full Text PDFJ Ethnopharmacol
January 2024
Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, The MOE Key Laboratory for Standardization of Chinese Medicines, Shanghai R&D Centre for Standardization of Chinese Medicines, 1200 Cailun Road, Shanghai, 201203, China. Electronic address:
Ethnopharmacological Relevance: Alzheimer's disease (AD) is a progressive developmental neurodegenerative disease that primarily develops in old age. Memory impairment is an important manifestation of AD. It has been demonstrated that inflammation and oxidative stress are important mediators in the development and progression of AD.
View Article and Find Full Text PDFCrit Rev Anal Chem
November 2024
The SATCM Key Laboratory for New Resources & Quality Evaluation of Chinese Medicine, Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
plants, as a kind of medicinal and edible herb, have a long history of application and have been widely concerned by pharmacists and biologists. In this article, the species diversity, taxonomy and distribution, ethnic medicinal records, chemical composition, pharmacological activity, and quality evaluation methods of species were systematically reviewed. In addition, the research progress of plants using biotechnology in recent years was summarized.
View Article and Find Full Text PDFZhongguo Zhong Yao Za Zhi
April 2023
State Key Laboratory Breeding Base of Dao-di Herbs, National Resource Center for Chinese Materia Medica,China Academy of Chinese Medical Sciences Beijing 100700, China.
Codonopsis Radix is a traditional tonic medicine commonly used in China, which has the effects of strengthening the spleen and tonifying the lung, as well as nourishing blood and engendering liquid. The chemical constituents of Codonopsis species are mainly polyacetylenes, alkaloids, phenylpropanoids, lignans, terpenoids and saponins, flavonoids, steroids, organic acids, saccharides, and so on. Modern pharmacological studies showed that Codonopsis Radix also has a variety of pharmacological effects such as enhancing body immunity, protecting gastrointestinal mucosa and resisting ulcers, promoting hematopoietic function, regulating blood sugar, and delaying aging.
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