In vitro and in vivo antibacterial activity of metronidazole preparations was studied in comparison to that of nitazole in various dosage forms: solution, aerosol, suspension and suppository. The metronidazole preparations inhibited only anaerobic organisms and were efficient in experimental infections caused by them. Unlike the metronidazole preparations, the dosage forms of nitazole inhibited the growth not only of anaerobic organisms but also that of staphylococci and had a therapeutic effect on infections caused by these organisms.
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