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The impact of Charcot-Leyden Crystal protein on mesothelioma chemotherapy: targeting eosinophils for enhanced chemosensitivity.
EBioMedicine
November 2024
Molecular and Cellular Epigenetics (GIGA) and Molecular Biology (TERRA), University of Liege, Liege & Gembloux, Belgium. Electronic address:
Background: In mesothelioma (MPM), clinical evidence indicates that the absolute eosinophil count negatively correlates with overall survival and response to standard chemotherapy. Since eosinophils poorly infiltrate MPM tumours, we hypothesised that endocrine rather than paracrine pathways mediate the therapeutic response. We thus studied the effect of eosinophil-associated factors on response to chemotherapy in mesothelioma.
View Article and Find Full Text PDFPresence of sputum IgG against eosinophilic inflammatory proteins in asthma.
Front Immunol
August 2024
State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health; Department of Allergy and Clinical Immunology, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, China.
Background: Sputum immunoglobulin G (Sp-IgG) has been discovered to induce cytolytic extracellular trap cell death in eosinophils, suggesting a potential autoimmune mechanism contributing to asthma. This study aimed to explore the potential origin of Sp-IgG and identify clinically relevant subtypes of Sp-IgG that may indicate autoimmune events in asthma.
Methods: This study included 165 asthmatic patients and 38 healthy volunteers.
Atypical -Induced Hepatic Visceral Larva Migrans: Diagnostic Challenges and Literature Review.
Korean J Gastroenterol
June 2024
Department of Internal Medicine, University of Medicine and Pharmacy at Ho Chi Minh City, Vietnam.
Article Synopsis
- Toxocariasis is a zoonotic infection from dog and cat larvae that can pose serious health risks to humans, with a case described involving a 21-year-old male who had close contact with a pet dog.
- The patient's symptoms initially resembled a common liver abscess, with lab results showing elevated white blood cells and IgE levels, but persistent fever led to more testing revealing a Toxocara-induced liver abscess.
- Successful treatment with albendazole demonstrated significant improvement, highlighting the importance of considering toxocariasis in liver abscess cases, especially in regions with high rates of infection, and the need for thorough diagnostic methods beyond serological tests.
Predictive significance of Charcot-Leyden crystal structures for nasal polyp recurrence.
Clin Transl Allergy
November 2022
Department of Otolaryngology-Head and Neck Surgery, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China.
Background: Charcot-Leyden crystals (CLCs) are recognized to be classic hallmarks of eosinophilic inflammation. Both protein and mRNA levels of CLC in nasal secretions and nasal brushing samples have been associated with nasal polyp recurrence. However, whether the crystalline CLC structures in nasal tissue could serve as an effective biomarker to predict polyp recurrence remains unclear.
View Article and Find Full Text PDFAn Integrated Analysis of Inflammatory Endotypes and Clinical Characteristics in Chronic Rhinosinusitis with Nasal Polyps.
J Inflamm Res
September 2022
Department of Otolaryngology-Head and Neck Surgery, Shandong Provincial ENT Hospital, Shandong University, Jinan, Shandong, People's Republic of China.
Objective: Chronic rhinosinusitis with nasal polyps (CRSwNP) is mainly characterised by type 1 (T1), type 2 (T2) and type 3 (T3) inflammatory endotypes. However, correlations between inflammatory endotypes and clinical features in CRSwNP have not been demonstrated sufficiently. This study aimed to determine the endotype-phenotype associations in CRSwNP.
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