Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
Application of autologous platelet rich plasma in Sun's procedure for acute type A aortic dissection under moderate hypothermia.
Front Cardiovasc Med
February 2025
Department of Cardiovascular Surgery, Qilu Hospital, Shandong University, Jinan, Shandong, China.
Background: Coagulopathy and inflammatory response are the intractable complication during Sun's procedure for type A aortic dissection (AAD). This study aims to investigate the efficacy of autologous platelet rich plasma (aPRP) on the patients undergoing Sun's procedure under moderate hypothermia.
Methods: A total of 372 AAD patients who underwent Sun's procedure under moderate hypothermia were divided into aPRP group (aPRP was separated before heparinization and transfused after protamine neutralization) and Non-aPRP group (without aPRP apheresis).
Effects of Protamine Reversal on Coagulation Parameters After High-Dose Heparin Administration in Percutaneous Hepatic Chemosaturation Intervention.
Clin Pract
February 2025
Department of Anesthesiology and Intensive Care Medicine, University Hospital Leipzig, Liebigstr. 20, 04103 Leipzig, Germany.
Background: Intravenous protamine administration for heparin reversal after percutaneous hepatic chemosaturation intervention is generally recommended, but its effectiveness on coagulation parameters remains unclear.
Methods: In a single-center retrospective observational study, the effects of different postinterventional protamine doses on the activated partial thromboplastin time (aPTT), international normalized ratio (INR), prothrombin time (PT), fibrinogen, platelet count (PLT), and hemoglobin (Hb) were analyzed in consecutive patients who underwent high-dose heparin administration (>300 U/kg body weight) and extracorporeal circulation for chemosaturation treatment. Due to the multiple treatments of individual patients, linear mixed-effects models were applied.
Cationic liposomes as broad-spectrum antidotes for heparin-based anticoagulants.
Acta Biomater
March 2025
School of Nanoscience and Engineering, School of Chemical Sciences, University of Chinese Academy of Sciences, Beijing 101408, PR China; The Comprehensive Breast Care Center, the Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710061, PR China. Electronic address:
Heparin-based anticoagulants have been widely used for the prevention and treatment of venous thrombotic diseases, as well as for anticoagulation during cardiopulmonary bypass and hemodialysis. However, excessive heparin usage brings serious bleeding risk, necessitating immediate reversal of their anticoagulant activity. Additionally, to prevent bleeding during surgery and restore hemostatic function post-cardiopulmonary bypass and hemodialysis, it is also crucial to reverse heparin's anticoagulant effects.
View Article and Find Full Text PDFAggregachromic Fluorogenic Asymmetric Cyanine Probes for Sensitive Detection of Heparin and Protamine.
Molecules
January 2025
Max Planck Institute for Polymer Research, Ackermannweg 10, 55128 Mainz, Germany.
The precise and fast detection of heparin, the most widely used anticoagulant, remains a significant challenge for assessing its use in a clinical setting. In this work, we adapt a well-established asymmetric cyanine fluorogenic platform for the purpose of ultrasensitive heparin detection in the presence of common interferant chemical species. Three analogous fluorescence probes are synthesized in order to optimize for the number of binding moieties.
View Article and Find Full Text PDFEffect of Ultrasonic Intensity Treatment on the Physicochemical and Functional Properties of Protamine.
Foods
February 2025
School of Food Science and Technology, Shihezi University, Shihezi 832003, China.
As the most valuable protein in the sperm of testes tissues of , protamine (CPP) had a natural antibacterial and antiseptic effect, but its physicochemical properties and functions are easily affected by the ultrasound-assisted extraction process. In this study, ultrasound-assisted extraction of CPP was used to investigate the effects of different ultrasonic intensities (0, 3.03, 6.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!