The results of immunomorphologic and histochemical investigations of 12 rabbits with experimental syringomyelia are presented. Chronic pachymeningitis of the hind brain, resulting from the administration of kaolin leads to the disorders of liquor circulation on the level of outlet of the fourth ventricle this being a start mechanism for the cavity formation in the spinal cord. The reactive inflammatory, degenerative and immune reactions accompany the formation of cavity in the nervous tissue. The formation of cavity is followed by asymmetrical segment demyelination and reparative hyperplasia of the astroglial cells and gliosis of the cavity walls.
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