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Development and utilization of expressing green fluorescent protein to study spirochete-host interactions and antibody-mediated clearance: expanding the toolbox for syphilis research.
mBio
January 2025
Department of Medicine, University of Connecticut Health, Farmington, Connecticut, USA.
Article Synopsis
- Syphilis, caused by a spirochetal pathogen, can lead to serious health complications if untreated, necessitating new strategies to understand its complex pathogenesis.
- This study engineered a strain of the syphilis bacteria that expresses green fluorescent protein (GFP), allowing researchers to visualize its interactions with host cells and evaluate its infectivity in a rabbit model.
- The findings emphasize the role of specific antibody responses in targeting the bacteria's outer membrane, highlighting potential targets for protective immunity and paving the way for future research on spirochetal-host interactions.
Development and utilization of expressing green fluorescent protein to study spirochete-host interactions and antibody-mediated clearance: expanding the toolbox for syphilis research.
bioRxiv
October 2024
Department of Medicine, University of Connecticut Health, Farmington, CT, USA.
Syphilis is a sexually transmitted infection caused by the highly invasive and immunoevasive spirochetal pathogen subsp. (). Untreated syphilis can lead to infection of multiple organ systems, including the central nervous system.
View Article and Find Full Text PDFThe potential risk of human exposure to tick borne infection by Borrelia burgdorferi sensu lato, Anaplasma phagocytophilum, and Babesia microti in selected recreational areas of the Poprad Landscape Park in southern Poland.
Ann Agric Environ Med
September 2024
Department of Medical and Molecular Biology, Faculty of Medical Sciences in Zabrze, Medical University of Silesia, Katowice, Poland.
Article Synopsis
- Ticks, specifically Ixodes ricinus, are harmful ectoparasites that transmit various pathogens, including those causing Lyme disease, anaplasmosis, and babesiosis to humans while they feed.
- A study was conducted in Poprad Landscape Park, Poland, where researchers collected and analyzed 363 ticks to assess the risk of these infections.
- Results showed that 19.6% of the ticks carried pathogens, with 11.8% testing positive for Borrelia burgdorferi, 7.4% for Babesia microti, and a lower percentage of 0.3% for Anaplasma phagocytophilum, indicating a significant risk of human exposure to these infections in the
Universal All-In-One Lateral Flow Immunoassay with Triple Signal Amplification for Ultrasensitive and Simple Self-Testing of Antibodies.
Anal Chem
November 2024
Institute for Chemical Biology and Biosensing, College of Life Sciences, Qingdao University, Qingdao 266071, China.
Lateral flow immunoassay (LFIA) is valued for its simplicity and rapidity for on-site screening, however, it experienced false negatives in real sample analysis due to low sensitivity. Although many signal amplification techniques can improve the sensitivity, they usually require additional complicated steps. To address these issues, taking () antibodies as a model detecting target, herein, we report an all-in-one LFIA (AIO-LFIA) with triple-step signal amplification to significantly improve sensitivity while maintaining simplicity.
View Article and Find Full Text PDFMultiplex Loop-Mediated Isothermal Amplification Coupled Lateral Flow Assay for Point-of-Care Detection of Syphilis.
Indian J Microbiol
September 2024
Department of Genetic Engineering, School of Bioengineering, Faculty of Engineering and Technology, SRM Institute of Science and Technology, SRM Nagar, Kattankulathur, Kanchipuram, Chennai, Tamil Nadu 603203 India.
Unlabelled: Syphilis is a re-emerging sexually transmitted disease caused by the pathogenic spirochete Every year more than 5 million cases are reported globally. The current diagnostic methods are primarily based on serological assays, which are less sensitive at an early stage of infection. To improve the disease diagnosis, there is a need to develop a rapid, simple, sensitive, and cost-effective point-of-care application, which plays an effective role in the detection of syphilis infection.
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