Several compounds derived from benzamidines and nicotinic pyridinic amidines with a structure similar to that of procainamide, exhibit notable antiarrhythmic properties after injection into animals. The diffusion rate of these different compounds through a solid lipidic artificial membrane was studied with Dibbern's apparatus. A statistical relation was established between the diffusion rate and the principal pharmacological parameters obtained after intraperitoneal injection (toxicity and anthiarrhythmic activity). Essential structural elements seem to determine a better bioavailability than procainamide: character of the substitution (in para) of the benzenic cycle; length of the lateral chain.
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Department of Chemistry, College of Science, King Saud University, PO Box 2455, Riyadh, 11541, Saudi Arabia.
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J Glob Antimicrob Resist
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Department of Radiology, Albert Einstein College of Medicine and Montefiore Medical Center, Bronx, NY, USA. Electronic address:
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School of Resources, Environment and Materials, Guangxi University, Nanning 530004, China. Electronic address:
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