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DeepQA: A Unified Transcriptome-Based Aging Clock Using Deep Neural Networks.
Aging Cell
January 2025
College of Artificial Intelligence, Nankai University, Tianjin, China.
Understanding the complex biological process of aging is of great value, especially as it can help develop therapeutics to prolong healthy life. Predicting biological age from gene expression data has shown to be an effective means to quantify aging of a subject, and to identify molecular and cellular biomarkers of aging. A typical approach for estimating biological age, adopted by almost all existing aging clocks, is to train machine learning models only on healthy subjects, but to infer on both healthy and unhealthy subjects.
View Article and Find Full Text PDFExperiments to simulate the salinisation process of loess under a dynamic water cycle.
Environ Res
January 2025
State Key Laboratory of Continental Dynamics, Northwest University, Xi'an, 710069, China.
Addressing loess salinisation is a crucial element in preserving ecological stability and fostering sustainable development in the northwest Loess Plateau. To investigate the impacts of salt solution on the properties of loess, independently designed salt solution-loess dynamic cyclic erosion equipment was used to soak the loess. Then, numerous tests were performed to analyse the variability of the effects of salt solution concentrations (SSC) and type, as well as the duration of soaking time, on these physico-mechanical properties.
View Article and Find Full Text PDFImmunization with OPN5 increased seasonal degradation of reproductive activity in Magang ganders.
Poult Sci
January 2025
College of Animal Science and Technology, Hunan Agricultural University, Changsha 410128, China. Electronic address:
To investigate the regulatory mechanism mediated by hypothalamic OPN5 on seasonal changes in the reproductive activities of domestic geese, 60 Magang ganders in their breeding period were selected for the experiment and evenly divided into an immunization group(OPN5-IM) and a control group. On days 0, 15 and 30, ganders in the immunized group were immunized with OPN5-KLH protein vaccine, and ganders in the control were immunized with the same amount of blank emulsified vaccine. Additionally, 120 female geese were provided to stimulate the reproductive activities of male geese.
View Article and Find Full Text PDFMultiscale X-ray scattering elucidates activation and deactivation of oxide-derived copper electrocatalysts for CO reduction.
Nat Commun
January 2025
Inorganic Chemistry and Catalysis, Debye Institute for Nanomaterials Science and Institute for Sustainable and Circular Chemistry, Faculty of Science, Utrecht University, Utrecht, The Netherlands.
Electrochemical reduction of carbon dioxide (CO) into sustainable fuels and base chemicals requires precise control over and understanding of activity, selectivity and stability descriptors of the electrocatalyst under operation. Identification of the active phase under working conditions, but also deactivation factors after prolonged operation, are of the utmost importance to further improve electrocatalysts for electrochemical CO conversion. Here, we present a multiscale in situ investigation of activation and deactivation pathways of oxide-derived copper electrocatalysts under CO reduction conditions.
View Article and Find Full Text PDFThe Role of Acetylcholinesterase Enzyme Inhibitor Rivastigmine on Spike-Wave Discharges, Learning-Memory, Anxiety, and TRPV1 Channel Expression in Genetic Absence Epileptic WAG/Rij Rats.
Neurochem Res
January 2025
Department of Physiology, Faculty of Medicine, University of Ondokuz Mayıs, Samsun, Türkiye.
In the present study, the effects of the acetylcholinesterase (AChE) enzyme inhibitor rivastigmine (RIVA) on spike-wave discharges (SWDs), memory impairment, anxiety-like behavior, and the transient receptor potential vanilloid 1 (TRPV1) gene expression were investigated in genetic absence epileptic Wistar Albino Glaxo/Rijswijk (WAG/Rij) rats. After tripolar electrodes were implanted on the WAG/Rij rats' skulls, single doses of 0.125, 0.
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