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Sound and Alzheimer's Disease-From Harmful Noise to Beneficial Soundscape Augmentation and Music Therapy.
Noise Health
January 2025
Institute of Hygiene and Medical Ecology, Faculty of Medicine, University of Belgrade, Belgrade, Serbia.
Exposure to sound energy may be a risk factor or a therapeutic intervention for Alzheimer's disease (AD). On one hand, noise has a harmful effect on people with AD by contributing to hearing loss, sleep disturbance, oxidative stress, inflammation, and excitotoxicity. But on the other hand, clinical trials and nursing home interventions with soundscape augmentation involving natural sounds have shown promising results in alleviating psychophysiological symptoms in people with AD.
View Article and Find Full Text PDFUpdate on aspirin exacerbated respiratory disease with chronic rhinosinusitis.
Curr Opin Allergy Clin Immunol
February 2025
Ellsworth and Mabel Simmons Professor of Allergy and Immunology, Section Chief, Allergy/Immunology James A. Haley VA Hospital, Morsani College of Medicine, University of South Florida, Tampa, Florida, USA.
Purpose Of Review: This review provides the current understanding on the mechanism, diagnosis, and treatment of aspirin exacerbated respiratory disease (AERD) with chronic rhinosinusitis (CRS).
Recent Findings: Updates focus on the current understanding of type 2 inflammation as a disease driver, alterations in gene expression in nasal polyps, and use of biologics in treating aspirin exacerbated respiratory disease. Recent findings include altered expression of GATA binding protein 3 (GATA3), interleukin (IL)-4, IL-5, and IL-17 in nasal polyps supports the current understanding that type 2 inflammation predominantly drives the pathophysiology of AERD with CRS.
The immunomodulatory effects of psychedelics in Alzheimer's disease-related dementia.
Neuroscience
January 2025
Cellular and Molecular Biology Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran; Department of Pharmacology and Toxicology, Faculty of Medicine, Babol University of Medical Sciences, Babol, Iran.
Dementia is an increasing disorder, and Alzheimer's disease (AD) is the cause of 60% of all dementia cases. Despite all efforts, there is no cure for stopping dementia progression. Recent studies reported potential effects of psychedelics on neuroinflammation during AD.
View Article and Find Full Text PDFUtilizing C-Reactive Protein (CRP) and CRP Ratios for Early Detection of Postoperative Complications Following Rectal Cancer Surgery.
Life (Basel)
November 2024
Department of Surgery, Carol Davila University of Medicine and Pharmacy, 020021 Bucharest, Romania.
Background: Surgical treatment for rectal cancer may cause complications that exacerbate the condition, lengthen hospital stays, and raise healthcare costs. Rectal cancer surgery complications can be detected immediately with postoperative C-reactive protein (CRP) monitoring. Elevated levels of CRP indicate the presence of inflammation and can serve as a predictive factor for future outcomes.
View Article and Find Full Text PDF[Hepatocellular carcinoma: Histological and molecular classifications].
Ann Pathol
November 2024
Université Paris Cité, Paris, France; Département de pathologie, FHU MOSAIC, SIRIC InSitu, hôpital Beaujon, AP-HP. Nord, Clichy, France; Centre de recherche sur l'inflammation, Inserm, UMR 1149, Paris, France.
Article Synopsis
- Hepatocellular carcinoma (HCC) is the most common type of liver cancer and has a poor prognosis, contributing significantly to cancer-related deaths globally.
- The tumor exhibits both morphological and molecular diversity, with the World Health Organization identifying eight subtypes based on histological characteristics, including steatohepatitic and macrotrabecular massive (MTM), some of which are linked to worse survival rates.
- Genomic analysis shows common mutations like TERT, as well as later mutations in TP53 and CTNNB1, with TP53 mutations correlating to poorer outcomes, emphasizing the need for detailed subtype classification for better prognosis assessments.
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