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Mercury(II)-Triggered Targeted and NIR-II Fluorescence/Photoacoustic Imaging Probe for High-Sensitivity Early Diagnosis and Evaluating Drug against Acute Liver and Kidney Injury.
Anal Chem
January 2025
State Key Laboratory of Applied Organic Chemistry and Key Laboratory of Nonferrous Metal Chemistry and Resources Utilization of Gansu Province, College of Chemistry and Chemical Engineering, Lanzhou University, Gansu, Lanzhou 730000, China.
Mercury ions (Hg) have been found to disrupt the body's antioxidant defense mechanisms, leading to oxidative stress and physiological dysfunction. Early diagnosis and real-time monitoring of Hg fluctuations in organ damage are crucial but limited due to the lack of noninvasive and deep tissue imaging probes. Herein, a Hg-triggered targeted and NIR-II fluorescence/photoacoustic (PA) dual-mode molecular probe (NHG-2) was developed for real-time monitoring Hg fluctuations in Hg-induced acute liver and kidney injury mice.
View Article and Find Full Text PDFN-acetylcysteine modulates markers of oxidation, inflammation and infection in tuberculosis.
J Infect
January 2025
The Aurum Institute, Johannesburg, South Africa; Case Western Reserve University, Cleveland USA; Department of Medicine, Vanderbilt University, Nashville USA.
Background: Half the global tuberculosis health burden is due to post-tuberculosis lung disease. Host-directed therapies have been proposed to reduce this burden. N-acetylcysteine (NAC) provides the conditionally essential amino acid cysteine required for synthesis of glutathione, an antioxidant thiol.
View Article and Find Full Text PDFMicrovascular dysfunction, mitochondrial reprogramming, and inflammasome activation as critical regulators of ischemic stroke severity induced by chronic exposure to prescription opioids.
J Neurosci
January 2025
University of Miami Miller School of Medicine, Department of Biochemistry and Molecular Biology, Miami, FL 33136.
The opioid epidemic endangers not only public health but also social and economic welfare. Growing clinical evidence indicates that chronic use of prescription opioids may contribute to an elevated risk of ischemic stroke and negatively impact post-stroke recovery. In addition, NLRP3 inflammasome activation has been related to several cerebrovascular diseases, including ischemic stroke.
View Article and Find Full Text PDFThe impact of N-acetylcysteine on hypoxia-induced testicular apoptosis in male rats: TUNEL and IHC findings.
Heliyon
November 2024
Department of Anatomical sciences, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.
Article Synopsis
- The study investigated the effects of N-acetylcysteine (NAC) on testicular hypoxia caused by varicocele in mature Wistar rats, focusing on gene regulation related to apoptosis and oxidative stress.
- Thirty-two rats were divided into four groups (Control, hypoxia, hypoxia treated with NAC, and healthy animals treated with NAC), with significant improvements in testicular health observed in the NAC-treated group after eight weeks.
- Results showed that NAC increased antioxidant levels and reduced markers of oxidative stress, lowered apoptosis rates in germ cells, and improved histopathological parameters, indicating its potential as a protective treatment for testicular damage from hypoxia.
Comparison of oxidative stress status in the kidney tissue of male rats treated with paraquat and nanoparaquat.
Sci Rep
January 2025
Department of Clinical Biochemistry, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran.
The study aimed to compare the oxidative stress status in the kidney tissue of rats treated with paraquat and nanoparaquat. The levels of oxidative stress markers, including malondialdehyde (MDA), total antioxidant capacity (TAC), and thiol groups (TTG), were measured in the kidney tissue samples. A total of forty male Wistar rats were randomly assigned to eight groups, each consisting of five rats: a control group, a paraquat (PQ) group, an N-acetylcysteine (NAC) group, groups receiving nanoparaquat α and β (α and β), groups receiving PQ and NAC (PQ + NAC), and groups receiving nanoparaquat α and β with NAC (+ NACα and β).
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