Thalidomide treatment attenuates chemotherapy-induced gonadal toxicity.

Fertil Steril

Department of Obstetrics, Gynecology, and Reproductive Sciences, University of Pittsburgh School of Medicine, Magee-Womens Research Institute, Pittsburgh, Pennsylvania 15213, USA.

Published: February 2011

The aim of this study was to investigate gonadal-protective properties of thalidomide in a mouse model of chemotherapy-induced ovarian failure. Administration of thalidomide before alkylating chemotherapy preserved ovarian follicles and lead to the resumption of normal estrous cyclicity.

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Source
http://dx.doi.org/10.1016/j.fertnstert.2010.09.020DOI Listing

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