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Breaking the link: IL-6 targeting to uncouple toxicity and efficacy in patients treated with immune checkpoint blockade.
Ann Oncol
January 2025
Drug Development Department (DITEP), Gustave Roussy, Villejuif; Faculty of Medicine, Paris Saclay University, Le Kremlin Bicêtre; Institut National de La Santé Et de La Recherche Médicale (INSERM), U1015 & CIC1428, Laboratoire de Recherche Translationnelle en Immunothérapie (LRTI), Villejuif, France.
Ribosomes translocation into the spore of Bacillus subtilis is highly organised and requires peptidoglycan rearrangements.
Nat Commun
January 2025
Institute of Biochemistry and Biophysics, Polish Academy of Sciences, Warsaw, Poland.
In the spore-forming bacterium Bacillus subtilis transcription and translation are uncoupled and the translational machinery is located at the cell poles. During sporulation, the cell undergoes morphological changes including asymmetric division and chromosome translocation into the forespore. However, the fate of translational machinery during sporulation has not been described.
View Article and Find Full Text PDFS-Nitrosylation of Dexras1 Controls Post-Stroke Recovery via Regulation of Neuronal Excitability and Dendritic Remodeling.
CNS Neurosci Ther
January 2025
Department of Pharmacy, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing, Jiangsu, China.
Aims: Stroke is a major public health concern leading to high rates of death and disability worldwide, unfortunately with no effective treatment available for stroke recovery during the repair phase.
Methods: Photothrombotic stroke was induced in mice. Adeno-associated viruses (AAV) were microinjected into the peri-infarct cortex immediately after photothrombotic stroke.
Divergent selection for basal metabolic rate in mice affects the abundance of UCP1 protein: implications for translational studies.
J Physiol
December 2024
Faculty of Biology, University of Białystok, Białystok, Poland.
Low basal metabolic rate (BMR) is a risk factor for obesity, whereas elevation of non-shivering thermogenesis (NST) is a promising means to combat obesity. Because heat generated by NST covers thermogenic needs not fulfilled by BMR, one can expect the presence of a negative relationship between both parameters. Understanding of the mechanisms underlying this relationship is therefore important for interpretation of the results of translational experiments and the development of anti-obesity treatments.
View Article and Find Full Text PDFMelatonin-Supplemented Obese Female Mice Show Less Inflammation in Ovarian Adipocytes and Browning in Subcutaneous Adipocytes.
Cell Biochem Funct
December 2024
Laboratory of Morphometry, Metabolism and Cardiovascular Disease, Biomedical Center, The University of the State of Rio de Janeiro, Rio de Janeiro, Brazil.
We hypothesized that melatonin (Mel) supplementation may offer therapeutic benefits for obesity, particularly in women. Therefore, the study evaluated Mel's effects on white adipose tissue (WAT) in diet-induced obese female mice. Four-week-old C57BL/6 females were assigned to either a control diet (C group) or a high-fat diet (HF group) for 6 weeks (n = 20/group).
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