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Identification of a red-emitting fluorescent ligand for in vitro visualization of human serotonin 5-HT(1A) receptors. | LitMetric
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Identification of a red-emitting fluorescent ligand for in vitro visualization of human serotonin 5-HT(1A) receptors.

Enza Lacivita Anna Carmela Masotti Md Jafurulla Roopali Saxena Nandini Rangaraj Amitabha Chattopadhyay Nicola A Colabufo Francesco Berardi Roberto Perrone Marcello Leopoldo

Bioorg Med Chem Lett

Università degli Studi di Bari A. Moro, Dipartimento Farmaco-Chimico, via Orabona, 4, 70125 Bari, Italy.

Published: November 2010

The 5-HT(1A) receptor subtype is the most thoroughly studied serotonin receptor subtype. We report here the design, synthesis and characterization of two new fluorescent ligands for the 5-HT(1A) receptor. The new 1-arylpiperazine-based red-emitting fluorescent compound 6 displayed good binding affinity at the 5-HT(1A) receptor (K(i)=35 nM) and was able to label specifically the human 5-HT(1A) receptor stably expressed in CHO cells visualized using confocal laser scanning microscopy.

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http://dx.doi.org/10.1016/j.bmcl.2010.09.027DOI Listing

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