AI Article Synopsis
- There is a global need for more donor livers, and this study examines the outcomes of elective liver transplantation patients in Argentina who received livers that were repeatedly refused by other centers.
- Between 2006 and 2009, 26 livers that met specific criteria of extensive refusal were transplanted, revealing that reasons for rejection often included poor donor status and program-specific conditions.
- The study found that outcomes such as primary graft non-function, in-hospital mortality, and one-year patient and graft survival rates were similar for both the rejected livers and the control group, highlighting the potential to decrease organ waste in the transplant process.
Article Abstract
Background: There is a worldwide need to expand the donor liver pool. We report a consecutive series of elective candidates for liver transplantation (LT) who received 'livers that nobody wants' (LNWs) in Argentina.
Methods: Between 2006 and 2009, outcomes for patients who received LNWs were analysed and compared with outcomes for a control group. To be defined as an LNW, an organ is required to fulfil two criteria. Firstly, each liver must be officially offered and refused more than 30 times; secondly, the liver must be refused by at least 50% of the LT programmes in our country before our programme can accept it. Principal endpoints were primary graft non-function (PNF), mortality, and graft and patient survival.
Results: We transplanted 26 LNWs that had been discarded by a median of 12 centres. A total of 2666 reasons for refusal had been registered. These included poor donor status (n= 1980), followed by LT centre (n= 398) or recipient (n= 288) conditions. Incidences of PNF (3.8% vs. 4.0%), in-hospital mortality (3.8% vs. 8.0%), 1-year patient (84% vs. 84%) and graft (84% vs. 80%) survival were equal in the LNW and control groups.
Conclusions: Transplantable livers are unnecessarily discarded by the transplant community. External and internal supervision of the activity of each LT programme is urgently needed to guarantee high standards of excellence.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2997657 | PMC |
| http://dx.doi.org/10.1111/j.1477-2574.2010.00193.x | DOI Listing |
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