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Gene expression profiling of peripheral blood leukocytes identifies potential novel biomarkers of chronic obstructive pulmonary disease in current and former smokers. | LitMetric
Background : Chronic obstructive pulmonary disease (COPD) is an inflammatory lung disease with associated systemic effects.Objective : To use gene expression microarrays in peripheral blood leukocytes of current and former cigarette smokers to identify differences associated with COPD.Materials And Methods : Random forest modelling and a split-sample case-control approach were used to identify candidate predictors.Results : We identified 1013 genes and one smoking exposure variable that differentiated current and former smokers with or without COPD. This predictor set was reduced to a nine-gene classifier (IL6R, CCR2, PPP2CB, RASSF2, WTAP, DNTTIP2, GDAP1, LIPE and RPL14).Conclusion : These gene expression profiles represent potential biomarkers for COPD and may help increase mechanistic understanding of the disease.
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