Losses are calculated for the single-mode graded-index- (GRIN-) lens coupler. The main advantage of this coupling system is large separation between fibers with small power loss. The excess loss of the GRIN-lens coupler is due primarily to the misalignments of the GRIN lenses and is most sensitive to angular tilt rather than lateral offset or end separation. The excess loss is calculated from the overlap of two differently sized or misaligned Gaussian beams. Experimental results show that this method is adequate for predicting losses that are due to misalignments of the GRIN lenses.
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http://dx.doi.org/10.1364/AO.33.003440 | DOI Listing |
J Otol
October 2024
Department of Otorhinolaryngology, the First Hospital of Jilin University, Changchun, 130021, Jilin, China.
Noise-induced hearing loss (NIHL) is primarily driven by inflammatory processes within the cochlea, where noise exposure triggers the activation of the NOD-like receptor protein 3 (NLRP3) inflammasome, leading to an inflammatory cascade. The interaction between increased NLRP3 expression and NF-κB activity can further amplify cochlear inflammation. Our findings reveal that (R)-PFI-2 hydrochloride, a selective inhibitor of the SETD7 enzyme, effectively inhibits the activation of the cochlear NF-κB pathway, suppresses the release of pro-inflammatory factors, and prevents inflammasome assembly.
View Article and Find Full Text PDFBackground: Obesity is a significant risk factor for chronic kidney disease (CKD), with metabolic bariatric surgery offering potential renal benefits. However, there is limited comparative data on the impact of Roux-en-Y gastric bypass (RYGB) versus laparoscopic sleeve gastrectomy (LSG) on renal function in individuals with obesity without end-stage renal disease (ESRD). The objective of this study was to compare renal function outcomes following RYGB and LSG in patients with obesity, focusing on estimated glomerular filtration rate (eGFR), serum creatinine, albumin-creatinine ratio (ACR), and serum cystatin C.
View Article and Find Full Text PDFObes Surg
January 2025
Sanatorio Allende of Cordoba, Córdoba, Argentina.
Background: Obesity is a chronic disease constituting a public health issue, and its prevalence is alarmingly on the rise worldwide. This disease represents a chronic and multifactorial condition, one of the factors being related to the psychological aspect of the patients. Bariatric is an effective tool for obesity control, with weight regain observed more frequently between the third and sixth postoperative years.
View Article and Find Full Text PDFLangenbecks Arch Surg
January 2025
Department of General, Visceral and Vascular Surgery, University Hospital of Jena, Am Klinikum 1, 07747, Jena, Germany.
Purpose: The prevalence of obesity, along with that of its associated health conditions, including cardiovascular diseases, diabetes mellitus, and liver diseases, such as non-alcoholic fatty liver disease (NAFLD), is increasing annually. Bariatric surgery is indicated for the treatment of obesity if conservative treatment fails. While various liver fibrosis scores have been proposed for assessing liver function, they are typically used prior to bariatric surgery.
View Article and Find Full Text PDFSurg Endosc
January 2025
Surgery Department, Hospital de Pedro Hispano, Matosinhos, Portugal.
Background: Sleeve gastrectomy (SG) is the most frequently performed bariatric surgery worldwide, offering effective weight loss and improvement in metabolic conditions. However, one of its major complications is the exacerbation or development of gastroesophageal reflux disease (GERD), affecting over 30% of patients. While Roux-en-Y gastric bypass (RYGB) is often the preferred alternative for patients with pre-existing GERD, it may not be suitable for all patients due to contraindications or patient preference.
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