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Annular secondary syphilis with HIV coinfection that resembles other dermatoses.

Dermatol Online J

August 2024

Department of Dermatology and Venereology, Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada, Yogyakarta, Indonesia Dr Sardjito General Hospital, Yogyakarta, Indonesia.

Syphilis is a sexually transmitted infection with manifestations that can mimic other diseases, leading to misdiagnosis. Annular syphilis is a rare atypical secondary syphilitic lesion that seldomly involves the face. Human immunodeficiency virus (HIV) coinfection can increasingly lead to atypical manifestations of syphilis and complicate the diagnosis.

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Erythema multiforme (EM) is an immune-mediated condition that manifests as targetoid skin lesions and can be triggered by various factors, including infections and vaccinations. This case report describes a 41-day-old full-term male infant who developed widespread annular, bullseye-shaped erythematous skin lesions one week after receiving the Bacillus Calmette-Guérin (BCG) vaccination. The infant, exclusively breastfed and without a significant past medical history, presented with these lesions but no associated systemic symptoms.

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Article Synopsis
  • Majocchi's granuloma is a dermatological condition where dermatophytes invade deeper skin layers, often triggered by trauma or excessive use of topical corticosteroids.
  • A 57-year-old man experienced itchy skin lesions on his right ankle after using over-the-counter steroids, leading to the diagnosis of Majocchi's granuloma evidenced by clinical and histopathological findings.
  • The patient was treated with oral terbinafine and topical luliconazole, resulting in resolution of lesions within three weeks, though he was advised to continue treatment for two months.
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Article Synopsis
  • A two-year-old girl experienced misdiagnoses such as tinea corporis and psoriasis, leading to ineffective treatments until a proper evaluation revealed her low zinc levels.
  • After being diagnosed with AE, she was treated with zinc sulfate, resulting in the complete resolution of her skin lesions within two weeks.
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