AI Article Synopsis
- Genetic variations in certain enzyme genes (CYPs and GSTs) may affect tumor development, with this study analyzing 5 specific variants in prostate cancer patients and controls.
- DNA was analyzed using PCR methods, and various statistical tools were employed to assess the data.
- The findings indicated a strong link between the CYP3A4 1B variant and prostate cancer, while the GSTT1 0 genotype was associated with increased risk in red meat consumers, suggesting these genetic factors could influence prostate cancer risk and progression.
Article Abstract
Background/objective: Genetic polymorphisms in cytochrome P-450 (CYPs) and glutathione S-transferase (GSTs) genes can influence the appearance of tumors by the formation of new enzymes with altered activities. In the present study, 5 polymorphic variants were examined in 154 patients with prostate carcinoma and in 154 controls.
Materials And Methods: DNA analysis was carried out through PCR-based methods. The statistical methods used were odds ratio and confidence interval (95% CI), χ(2), Fisher, and Mann-Whitney.
Results: The study showed absence of association for CYP1A1 2B, CYP1B1 2, GSTM1 0, and GSTT1 0. The statistical analysis implied a positive association of variant CYP3A4 1B for prostate cancer. The combined analysis of CYP1A1 2B, CYP1B1 2, and CYP3A4 1B genotypes showed positive association. The analysis of histopathologic parameters detected statistically significant differences for Gleason score and biochemistry recurrence risk. The presence of the GSTT1 0 genotype in red meat consumers increased the risk for this disease.
Conclusion: Some polymorphic variants analyzed can influence the development and the progression of prostate cancer.
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| http://dx.doi.org/10.1016/j.urolonc.2010.01.009 | DOI Listing |
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