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Treating Metabolic Dysregulation and Senescence by Caloric Restriction: Killing Two Birds with One Stone?
Antioxidants (Basel)
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Institute of Clinical Physiology, National Research Council, Via Moruzzi 1, 56124 Pisa, Italy.
Cellular senescence is a state of permanent cell cycle arrest accompanied by metabolic activity and characteristic phenotypic changes. This process is crucial for developing age-related diseases, where excessive calorie intake accelerates metabolic dysfunction and aging. Overnutrition disturbs key metabolic pathways, including insulin/insulin-like growth factor signaling (IIS), the mammalian target of rapamycin (mTOR), and AMP-activated protein kinase.
View Article and Find Full Text PDFGenetic structure of populations in wildlife of north and northeast Iran.
Int J Parasitol Parasites Wildl
April 2025
Department of Medical Parasitology & Mycology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.
is a parasite prevalent in the temperate regions of the vast Palearctic realm, including Iran. In this study, we investigated infection in road-killed animals and carcasses in northern and northeastern Iran by artificial digestion. We assessed species identification and intraspecific genetic diversity using the markers 5S ribosomal DNA intergenic spacer (5S rDNA), internal transcribed spacer I (ITS1), and cytochrome oxidase subunit I ().
View Article and Find Full Text PDFNematode controlling effects and safety tests of Duddingtonia flagrans biological preparation in sheep.
Sci Rep
January 2025
Rui Pu Agricultural Technology Co., Ltd, Hohhot, Inner Mongolia, People's Republic of China.
Duddingtonia flagrans is a nematode-trapping fungus that is widely used to control parasitic nematodes in livestock. After oral ingestion and passage through the digestive tract of animals, this microorganism captures nematodes in feces. Although many researchers have examined the safety of this fungus for humans, animals, and the environment, few reports have discussed the safety of nematode-trapping D.
View Article and Find Full Text PDFConstruction of efficient ethylene removal and antibacterial cellulose paper-based packaging materials for avocado preservation.
Int J Biol Macromol
January 2025
Department of Chemical Engineering, University of New Brunswick, Fredericton, New Brunswick E3B 5A3, Canada. Electronic address:
Fruits are susceptible to ethylene ripening and microbial infestation, which can lead to spoilage and further significant economic losses. Thus, using functional preservation materials is an effective controlling technology to improve the post-harvest quality and extend the shelf life of fruits. Hence, a dual-function cellulose-based paper with exceptional antibacterial efficiency, favourable ethylene removal performance, improved mechanical and hydrophobic properties was prepared by covalently grafted antibacterial guanidine salt and surface-modified ethylene scavenger.
View Article and Find Full Text PDFCovalent Grafting of Quaternary Ammonium Salt-Containing Polyurethane onto Silicone Substrates to Enhance Bacterial Contact-Killing Ability.
Polymers (Basel)
December 2024
School of Chemistry and Chemical Engineering, Tianjin University of Technology, 391 Binshuixidao, Tianjin 300384, China.
Catheter-associated urinary tract infection (CAUTI) induced by rapid bacterial colonization and biofilm formation on urinary catheters is a key issue that urgently needs to be addressed. To prevent CAUTI, many contact-killing, non-leaching coatings have been developed for the surfaces of silicone catheters. However, due to the chemical inertness of the silicone substrate, most current coatings lack adhesion and are unstable under external forces.
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