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Long-term impact of early identification of cerebral palsy.
Curr Opin Pediatr
January 2025
Shirley Ryan AbilityLab, Ann & Robert H. Lurie Children's Hospital of Chicago, Northwestern Feinberg School of Medicine, Chicago, Illinois, USA.
Purpose Of Review: Early identification of cerebral palsy (CP), as in all neurologic conditions, has a profound impact on the ability to initiate interventions, support the education and empowerment of parents, ameliorate the effect of the conditions, and importantly identifies cohorts for neuroprotection or repair to address the primary injury. CP is a life span condition. Rapid initiation of services, support and anticipatory guidance is essential to maximize functional outcomes, prevent or manage complications and improve quality of life.
View Article and Find Full Text PDFA randomised double-blind, placebo-controlled trial of pramipexole in addition to mood stabilisers for patients with treatment-resistant bipolar depression (the PAX-BD study).
J Psychopharmacol
January 2025
Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, UK.
Background: Options for 'treatment-resistant bipolar depression' (TRBD) are limited. Two small, short-term, trials of pramipexole suggest it might be an option.
Aims: To evaluate the clinical effectiveness and safety of pramipexole in the management of TRBD.
Professional training of prison service workers in the Czech Republic: historical development, aspects of importance and current challenges.
Int J Prison Health (2024)
January 2025
Department of Pedagogy, AMBIS vysoká škola, a.s./ AMBIS University, Prague, Czech Republic.
Purpose: The purpose of this paper is to analyse the historical development and current challenges of professional training for prison service staff in the Czech Republic. This study focuses on the transition from a repressive system under communism to a democratic approach emphasising human rights, ethics and professionalisation. It aims to assess the effectiveness of the current training programmes and their alignment with international standards, highlighting their impact on safety, recidivism reduction and prisoner re-socialisation.
View Article and Find Full Text PDFCannabinoid receptor 1 ligands: Biased signaling mechanisms driving functionally selective drug discovery.
Pharmacol Ther
January 2025
Xi'an Key Laboratory for Antiviral and Antimicrobial-Resistant Bacteria Therapeutics Research, Shaanxi University of Science & Technology, Xi'an 710021, China; School of Biological and Pharmaceutical Sciences, Shaanxi University of Science & Technology, Xi'an 710021, China. Electronic address:
G protein-coupled receptors (GPCRs) adopt conformational states that activate or inhibit distinct signaling pathways, including those mediated by G proteins or β-arrestins. Biased signaling through GPCRs may offer a promising strategy to enhance therapeutic efficacy while reducing adverse effects. Cannabinoid receptor 1 (CB1), a key GPCR in the endocannabinoid system, presents therapeutic potential for conditions such as pain, anxiety, cognitive impairment, psychiatric disorders, and metabolic diseases.
View Article and Find Full Text PDFEpilepsy, compulsion and oxytocin: Insights from behavioral sequences, using neuroethology and complexity systems approaches.
Epilepsy Behav
January 2025
Physiology Department, Ribeirão Preto, School of Medicine, University of São Paulo, (USP), Ribeirão Preto, Brazil; Neuroscience and Behavioral Sciences Department, Ribeirão Preto, School of Medicine, University of São Paulo, (USP), Ribeirão Preto, Brazil. Electronic address:
Epilepsies are complex neurological entities usually co-existing with neuropsychiatric comorbidities. We already demonstrated that microinjection of oxytocin (OT) into the central nucleus of amygdala (CeA) induces hypergrooming in Wistar rats, a model of compulsion. Furthermore, the Wistar Audiogenic Rat (WAR) strain is a genetic model of generalized tonic-clonic seizures.
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