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Association between circulating inflammatory proteins and temporomandibular disorders: insight from a two-sample Mendelian randomization analysis.
J Appl Oral Sci
January 2025
Shanghai Jiao Tong University School of Medicine, College of Stomatology, Shanghai Ninth People's Hospital, Department of Orthodontics, Shanghai, China.
Background: Past studies have indicated links between specific inflammatory proteins in the bloodstream and temporomandibular disorders (TMDs). Nonetheless, there remains the need for further solid research pinpointing the exact causes behind these associations. This Mendelian randomization (MR) study aims to examine the association between 91 circulating inflammatory proteins and TMDs.
View Article and Find Full Text PDFMolecular markers and cytogenetics of Eleven O'Clock Portulaca umbraticola: a non-conventional edible ornamental crop.
Braz J Biol
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Universidade Federal da Paraíba - UFPB, Centro de Ciências Agrárias - CCA, Areia, PB, Brasil.
Portulaca umbraticola, commonly known as "Eleven o'clock", is a popular ornamental plant in Brazil, but its potential as a non-conventional food source remains underexplored. Assessing its genetic and cytogenetic diversity is crucial for breeding and selecting optimal accessions. In this study, we analyzed the genetic diversity of P.
View Article and Find Full Text PDFMolecular analysis of zoonotic pathogens in free-ranging six-banded armadillos (Euphractus sexcinctus) from the Brazilian semiarid region.
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Hospital Veterinário Jerônimo Dix-Huit Rosado Maia, Universidade Federal Rural do Semi-Árido - UFERSA, Mossoró, RN, Brasil.
This study investigated infection by Leishmania spp., Leptospira spp., Toxoplasma gondii, and Trypanosoma cruzi in six-banded armadillos (Euphractus sexcinctus) from the semiarid region of northeastern Brazil.
View Article and Find Full Text PDF3D genomic features across >50 diverse cell types reveal insights into the genomic architecture of childhood obesity.
Elife
January 2025
Center for Spatial and Functional Genomics, The Children's Hospital of Philadelphia, Philadelphia, United States.
The prevalence of childhood obesity is increasing worldwide, along with the associated common comorbidities of type 2 diabetes and cardiovascular disease in later life. Motivated by evidence for a strong genetic component, our prior genome-wide association study (GWAS) efforts for childhood obesity revealed 19 independent signals for the trait; however, the mechanism of action of these loci remains to be elucidated. To molecularly characterize these childhood obesity loci, we sought to determine the underlying causal variants and the corresponding effector genes within diverse cellular contexts.
View Article and Find Full Text PDFAn ensemble deep learning framework for energy demand forecasting using genetic algorithm-based feature selection.
PLoS One
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Department of Information Systems and Cybersecurity, University of Bisha, Bisha, KSA.
Accurate energy demand forecasting is critical for efficient energy management and planning. Recent advancements in computing power and the availability of large datasets have fueled the development of machine learning models. However, selecting the most appropriate features to enhance prediction accuracy and robustness remains a key challenge.
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