Gordon Waddell's "Nonorganic Signs," published in 1980, indicates psychosocial factors that predict an unsuccessful surgical outcome for lumbar discectomy. Since then, they have been used by many to"prove" there is nothing physically wrong with such people, regardless of the site of injury, and even suggest they are faking. Although this was never Waddell's intent and there is no scientific basis for such belief, these signs continue to be used to discredit motor vehicle accident claimants. Recent advances in neuroanatomy now allow us to explain all these signs on the basis of known mechanisms and to understand that many are the result of maladaptive physical responses. They should be called behavioral responses to physical assessment and be used to promote more effective management.
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http://dx.doi.org/10.1097/PHM.0b013e3181f70eae | DOI Listing |
Transl Psychiatry
December 2024
Departments of Psychiatry and Human Genetics, The University of Chicago, Chicago, IL, USA.
Recent genetic studies have linked numerous loci to psychiatric disorders. However, the biological pathways that connect these genetic associations to psychiatric disorders' specific pathophysiological processes are largely unclear. Endophenotypes, first defined over five decades ago, are heritable traits, independent of disease state that are associated with a disease, encompassing a broad range of neurophysiological, biochemical, endocrinological, neuroanatomical, cognitive, and neuropsychological characteristics.
View Article and Find Full Text PDFJ Neurol
December 2024
Department of Neurology, Mayo Clinic in Florida, 4500 San Pablo Road S, Jacksonville, FL, 32224, USA.
Background And Objectives: The term rapid progressive dementia (RPD) may be applied to patients who develop dementia within 1 year or complete incapacitation within 2 years of the first symptom of impairment. However, in select cases, cognitive impairment may emerge abruptly, with symptoms evolving across hours or days. We sought to determine the frequency, etiologies, and factors that associated with ultra-RPD.
View Article and Find Full Text PDFJ Neurosci
December 2024
State Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, Beijing, China, 100875
The human brain exhibits high degree of individual variability in both its structure and function, which underlies inter-subject differences in cognition and behavior. It was previously shown that functional connectivity is more variable in the hetero-modal association cortex but less variable in the unimodal cortices. Structural connectivity is the anatomical substrate of functional connectivity, but the spatial and temporal patterns of individual variability in structural connectivity (IVSC) remain largely unknown.
View Article and Find Full Text PDFActa Neurochir (Wien)
December 2024
Division of Neurosurgery, Department of Clinical Neurosciences, Geneva University Hospitals, Geneva, Switzerland.
Background: Intraventricular tumors present significant surgical challenges due to their deep location and proximity to critical neuroanatomical structures. Surgical strategies include the transtemporal, interhemispheric and transparietal approaches, each carrying specific risks. Recently, a paramedian transparietal approach to a lateral ventricle meningioma in the dominant hemisphere was described.
View Article and Find Full Text PDFEMBO Mol Med
November 2024
Institut de Génétique et de Biologie Moléculaire et Cellulaire, IGBMC, Illkirch, F-67404, France.
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