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Conductive hydrogel luminal filler for peripheral nerve regeneration.
Biomaterials
January 2025
School of Materials Science and Engineering, Gwangju Institute of Science and Technology, Gwangju, 61005, Republic of Korea. Electronic address:
Peripheral nerve injuries impair quality of life due to pain and loss of sensory and motor functions. Current treatments like autografts and nerve guidance conduits (NGCs) have limitations in functional restoration. Luminal fillers can enhance the effectiveness of NGCs by providing beneficial intraneural environments.
View Article and Find Full Text PDFRisk of intrafascicular spread after deliberate ex vivo intraneural injections of brachial plexus nerve roots.
Br J Anaesth
February 2025
Department of Anesthesiology, University of Florida College of Medicine, Gainesville, FL, USA; CEU-San-Pablo University School of Medicine, Madrid, Spain; Department of Anesthesiology, Madrid-Montepríncipe University Hospital, Madrid, Spain. Electronic address:
Background: We investigated the intraneural spread of injected fluid in brachial plexus nerve roots, examining the potential for intrafascicular spread and identifying influencing factors.
Methods: Twelve deliberate ultrasound-guided intraneural injections were performed at the ventral rami of the brachial plexus nerve roots at their exits from the neuroforamina in six fresh, unembalmed, cryopreserved human cadavers. A 22-G, 30-degree bevel echogenic regional anaesthesia needle was used.
Real time continuous monitoring of injection pressure at the needle tip is better than ultrasound in early detecting intraneural injection.
Reg Anesth Pain Med
January 2025
Anesthesia, Ospedale Regionale di Bellinzona e Valli Bellinzona, Bellinzona, Switzerland.
Article Synopsis
- Inadvertent intraneural injections during peripheral nerve blocks are common, and this study compares two detection methods: injection pressure monitoring and ultrasound imaging.
- The research involved anesthesiologists conducting intraneural injections on fresh cadaver arms, measuring both pressure and sonographic images to evaluate outcomes.
- Results showed that pressure monitoring detected intraneural injection much earlier than ultrasound (after just 0.2 mL vs. 1.2 mL for swelling), confirming that pressure monitoring is a more sensitive technique.
Intraneural Device for Electrostimulation of Vagus Nerve in Rats: A Feasibility Study for Modulating Glucose Tolerance.
Neuromodulation
November 2024
Laboratory of Energy and Data Science, Division of Smart Sector Integration, Italian National Agency for New Technologies, Energy and Sustainable Economic Development, Casaccia Research Center, Rome, Italy. Electronic address:
Objectives: This study introduces EMPATIC (Electro-Modulation of PAncreaTic Islet Cells), a miniaturized intraneural device designed for transversal insertion into small nerves with a mean diameter of 400 μm. EMPATIC aims to modulate glucose tolerance through intraneural vagus nerve stimulation (VNS) in rats.
Materials And Methods: EMPATIC design was optimized to fit into the cervical vagus nerve of rats and was developd through thin film microtechnologies.
New prospects for Zr-immuno-PET in brain applications - Alpha-synucleinopathies.
Nucl Med Biol
November 2024
Amsterdam UMC location Vrije Universiteit Amsterdam, Dept Radiology & Nuclear Medicine, De Boelelaan 1117, Amsterdam, the Netherlands; Amsterdam Neuroscience, Brain Imaging, Amsterdam, the Netherlands. Electronic address:
Article Synopsis
- * Background research highlights how Zr-immuno-PET imaging can effectively visualize therapeutic antibodies utilizing transferrin-mediated transport across the blood-brain barrier and emphasizes the significance of alpha-synuclein in diseases like Parkinson’s.
- * The methodology involved conjugating antibodies with a chelator and using various analyses, including radioim
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