New 6-substituted and 2,6-disubstituted pyridazinone derivatives were obtained starting from easily accessible alkyl furans by using oxidation with singlet oxygen to give 4-methoxy or 4-hydroxybutenolides, key intermediates of this synthetic strategy. The new pyridazinone derivatives have been studied as vasorelaxant and antiplatelet agents. Analysis of biological data revealed the silyl ethers (4a-i) and N,O-dibenzyl derivatives (6g-i) as the most active compounds.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.bmcl.2010.09.031 | DOI Listing |
Publication Analysis
Top Keywords
pyridazinone derivatives
12
derivatives vasorelaxant
4
vasorelaxant platelet
4
platelet antiaggregatory
4
antiaggregatory activities
4
activities 6-substituted
4
6-substituted 26-disubstituted
4
26-disubstituted pyridazinone
4
derivatives starting
4
starting easily
4
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!