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Voxel-based lesion symptom mapping localizes residual visual function in hemianopia.
J Neurosci
January 2025
Wellcome Centre for Integrative Neuroimaging; Nuffield Department of Clinical Neuroscience, University of Oxford.
Damage to the primary visual cortex (V1) results in visual field deficits on the contralateral side of the world corresponding to the damaged region. Patients with such loss nonetheless show varying residual vision within this apparently blind region, with the neural mechanisms underlying this ability obscured by small study populations. We identified lesions on structural scans from 39 patients (12 female) with hemianopia and occipital lobe damage.
View Article and Find Full Text PDFEvaluation of rewarding effects of nitazene analogs: results from conditioned place preference tests and in vivo microdialysis experiments in mice.
J Toxicol Sci
January 2025
Department of Pharmaceutical and Environmental Sciences, Tokyo Metropolitan Institute of Public Health.
In illicit drug markets, the most recently expanding new synthetic opioid subclass is benzimidazoles, also known as nitazenes, which were originally developed as analgesics in the 1950s. The emergence of this classical, potent drug family has attracted extensive research interest in the field of forensic toxicology; however, information on their psychological and physical dependence is very limited. Herein, we evaluated the rewarding effects of four nitazene analogs using a battery of in vivo experiments, with a positive control drug (isotonitazene).
View Article and Find Full Text PDFTwo new sesquiterpenoids and two new diterpenoids from Croton lauioides with anti-inflammatory and cytotoxic activities.
Fitoterapia
January 2025
Key Laboratory for Forest Resources Conservation and Utilization in the Southwest Mountains of China, Ministry of Education, Southwest Forestry University, Kunming 650224, China; Yunnan Provincial Key Laboratory for Conservation and Utilization of In-forest Resource, Southwest Forestry University, Yunnan Kunming, 650224, China. Electronic address:
Two new tropolone-bearing sesquiterpenoids (1-2), two new dolabrane-type diterpenoids (3-4) along with eight known compounds as ionone-type sesquiterpenoid (5), oleanane triterpenoid (6), vanillin and its derivative (7-8), neolignan (9), two lignans (10-11), flavanonol glycoside (12) were isolated from whole plants of Croton lauioides Radcl.-Sm. & Govaerts.
View Article and Find Full Text PDFAdvances in the impact of ASS1 dysregulation on metabolic reprogramming of tumor cells.
Cell Signal
January 2025
Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Kunming Medical University, Yunnan, Kunming 650500, PR China. Electronic address:
ASS1(argininosuccinate synthase 1) is a rate-limiting enzyme in the urea cycle, catalyzing the synthesis of argininosuccinate from citrulline and aspartate to ultimately produce arginine and support cellular metabolism. Increasing evidence suggests that ASS1 is commonly dysregulated in the tumor microenvironment, promoting tumor cell metastasis and infiltration. With a deeper understanding of tumor metabolic reprogramming in recent years, the impact of ASS1 dysregulation on abnormal tumor metabolism has attracted growing interest among researchers.
View Article and Find Full Text PDFAssessing the forensic implications of DNA degradation for PMI estimation using comet assay: A systematic review.
J Forensic Leg Med
January 2025
Department of Forensic Medicine and Toxicology, All India Institute of Medical Sciences, Raipur, Chhattisgarh (C.G), India.
Accurate post-mortem interval estimation is crucial in forensic investigations, providing essential information for criminal cases. Traditional techniques frequently encounter inaccuracies stemming from environmental and individual variables. The comet assay is a very sensitive technique that detects DNA damage, which has emerged as a promising tool for assessing DNA degradation.
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