AI Article Synopsis
- This study examined the link between cystatin-C levels and the severity of metabolic syndrome in Asian Indians.
- Five groups of participants with varying numbers of metabolic risk factors were analyzed, with serum cystatin-C levels measured and found to decrease as the number of risk factors decreased.
- The results indicated that higher cystatin-C levels are strongly associated with more metabolic abnormalities, suggesting it could be a useful biomarker for assessing metabolic syndrome severity in this population.
Article Abstract
Background: This study looked at the association of cystatin-C (cys-C) with severity of metabolic syndrome in Asian Indians.
Methods: Five sets of normal glucose tolerance subjects were recruited from the Chennai Urban Rural Epidemiology Study (CURES), a population-based study in southern India: 43 subjects with no metabolic risk factors, 44 subjects with one metabolic risk factor, 37 subjects with two risk factors, 40 subjects with three risk factors, and 40 subjects with four or five metabolic risk factors. Metabolic syndrome was defined using National Cholesterol Education Program criteria for adults modified for waist measured using the World Health Organization Asia Pacific guidelines. Serum cys-C was estimated by a high-sensitivity particle-enhancing nephelometry assay.
Results: Subjects with four or five metabolic abnormalities had the highest cys-C levels, and with decreasing number of metabolic abnormalities, the cys-C levels decreased linearly (P for trend < 0.001). Regression analysis showed a linear increase in cys-C levels with increasing number of metabolic abnormalities.
Conclusion: Cys-C levels are highly correlated with the number of metabolic abnormalities in Asian Indians.
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| http://dx.doi.org/10.1089/dia.2010.0077 | DOI Listing |
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