The construction of a library of benzothiaoxazepine-1,1'-dioxides utilizing a one-pot, S(N)Ar diversification-ODCT(50) scavenging protocol is reported. This protocol combines microwave irradiation to facilitate the reaction, in conjunction with a soluble ROMP-derived scavenger (ODCT) to afford the desired products in good overall purity. Utilizing this protocol, a 78-member library was successfully synthesized and submitted for biological evaluation.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3098767 | PMC |
| http://dx.doi.org/10.1021/cc1001023 | DOI Listing |
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