A focused library of [4-(2-hydroxyphenyl)thiazol-2-yl]methanones was prepared in a four-step synthesis with the aim to obtain potent inhibitors of type III secretion in Gram-negative bacteria. The compounds are potential bioisosteres of salicylidene acylhydrazides that are a known class of type III secretion inhibitors.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6257736 | PMC |
| http://dx.doi.org/10.3390/molecules15096019 | DOI Listing |
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