Four Streptococcus pneumoniae isolates expressing both 6A and 6B capsular serotypes were detected by a multiplex immunoassay. The sequence of WciP, a GT2-family glycosyltransferase, indicates that point mutation has compromised linkage specificity, allowing two alternative oligosaccharides to be synthesized. This finding highlights that mutation as well as recombination can mediate serotype change.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2976087 | PMC |
| http://dx.doi.org/10.1128/CVI.00335-10 | DOI Listing |
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